Fourfold Filtered Statistical/Computational Approach for the Identification of Imidazole Compounds as HO-1 Inhibitors from Natural Products

Over-regulation of Heme oxygenase 1 (HO-1) has been recently identified in many types of human cancer, and in these cases, poor clinical outcomes are normally reported. Indeed, the inhibition of HO-1 is being considered as an anticancer approach. Imidazole scaffold is normally present in most of the...

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Autores principales: Floresta, Giuseppe, Amata, Emanuele, Gentile, Davide, Romeo, Giuseppe, Marrazzo, Agostino, Pittalà, Valeria, Salerno, Loredana, Rescifina, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409521/
https://www.ncbi.nlm.nih.gov/pubmed/30759842
http://dx.doi.org/10.3390/md17020113

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