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Sclerosing Pneumocytoma: A Ten-Year Experience at a Western Balkan University Hospital

Background and objective: Sclerosing pneumocytoma is a rare, benign tumor of the lung that represents a diagnostic challenge due to the diversity of pathohistological findings. The aim of this study was to present a 10-year experience with sclerosing pneumocytoma of a large center for the diagnosis...

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Autores principales: Lovrenski, Aleksandra, Vasilijević, Milena, Panjković, Milana, Tegeltija, Dragana, Vučković, Dejan, Baroš, Ilija, Lovrenski, Jovan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409643/
https://www.ncbi.nlm.nih.gov/pubmed/30691016
http://dx.doi.org/10.3390/medicina55020027
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author Lovrenski, Aleksandra
Vasilijević, Milena
Panjković, Milana
Tegeltija, Dragana
Vučković, Dejan
Baroš, Ilija
Lovrenski, Jovan
author_facet Lovrenski, Aleksandra
Vasilijević, Milena
Panjković, Milana
Tegeltija, Dragana
Vučković, Dejan
Baroš, Ilija
Lovrenski, Jovan
author_sort Lovrenski, Aleksandra
collection PubMed
description Background and objective: Sclerosing pneumocytoma is a rare, benign tumor of the lung that represents a diagnostic challenge due to the diversity of pathohistological findings. The aim of this study was to present a 10-year experience with sclerosing pneumocytoma of a large center for the diagnosis and treatment of pulmonary diseases, and to emphasize differential diagnostic dilemmas as a potential source of errors. Material and Methods: This represents a retrospective study of six patients diagnosed and treated with sclerosing pneumocytoma in the 10-year period. The study analyzed various parameters, which are: Sex, age, symptoms, size and localization of the tumor, and its gross and histological features. Results: Sclerosing pneumocytoma was more frequently diagnosed in females (83.34%). The patients ranged in age from 38 to 61. Most of the patients (66.66%) were asymptomatic. Two patients underwent a video-assisted thoracoscopic surgery, two patients had a video-assisted minithoracotomy, and two patients underwent a thoracotomy in order to remove the tumor. The tumor was localized in the left lower lobe, in the right upper lobe, and in the right lower lobe in 50%, 33.34%, and 16.66% of patients, respectively. The tumor size ranged from 1 to 2.5 cm. A pathohistological examination of all six cases reported that all four major histological patterns were found in tissue sections: solid, papillary, sclerosing, and hemorrhagic. In all six cases, an immunohistochemical analysis showed positive expression of TTF-1 and panCK in surface epithelial cells, and TTF-1 positivity and panCK negativity in round stromal cells. Conclusions: Sclerosing pneumocytoma is a strictly histological diagnosis supported by clinical and radiological findings and corresponding immunohistochemical methods. Lung pathologists should always keep this tumor in mind, since its spectrum of differential diagnosis is wide, and therefore it can be an important diagnostic pitfall.
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spelling pubmed-64096432019-03-25 Sclerosing Pneumocytoma: A Ten-Year Experience at a Western Balkan University Hospital Lovrenski, Aleksandra Vasilijević, Milena Panjković, Milana Tegeltija, Dragana Vučković, Dejan Baroš, Ilija Lovrenski, Jovan Medicina (Kaunas) Article Background and objective: Sclerosing pneumocytoma is a rare, benign tumor of the lung that represents a diagnostic challenge due to the diversity of pathohistological findings. The aim of this study was to present a 10-year experience with sclerosing pneumocytoma of a large center for the diagnosis and treatment of pulmonary diseases, and to emphasize differential diagnostic dilemmas as a potential source of errors. Material and Methods: This represents a retrospective study of six patients diagnosed and treated with sclerosing pneumocytoma in the 10-year period. The study analyzed various parameters, which are: Sex, age, symptoms, size and localization of the tumor, and its gross and histological features. Results: Sclerosing pneumocytoma was more frequently diagnosed in females (83.34%). The patients ranged in age from 38 to 61. Most of the patients (66.66%) were asymptomatic. Two patients underwent a video-assisted thoracoscopic surgery, two patients had a video-assisted minithoracotomy, and two patients underwent a thoracotomy in order to remove the tumor. The tumor was localized in the left lower lobe, in the right upper lobe, and in the right lower lobe in 50%, 33.34%, and 16.66% of patients, respectively. The tumor size ranged from 1 to 2.5 cm. A pathohistological examination of all six cases reported that all four major histological patterns were found in tissue sections: solid, papillary, sclerosing, and hemorrhagic. In all six cases, an immunohistochemical analysis showed positive expression of TTF-1 and panCK in surface epithelial cells, and TTF-1 positivity and panCK negativity in round stromal cells. Conclusions: Sclerosing pneumocytoma is a strictly histological diagnosis supported by clinical and radiological findings and corresponding immunohistochemical methods. Lung pathologists should always keep this tumor in mind, since its spectrum of differential diagnosis is wide, and therefore it can be an important diagnostic pitfall. MDPI 2019-01-25 /pmc/articles/PMC6409643/ /pubmed/30691016 http://dx.doi.org/10.3390/medicina55020027 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lovrenski, Aleksandra
Vasilijević, Milena
Panjković, Milana
Tegeltija, Dragana
Vučković, Dejan
Baroš, Ilija
Lovrenski, Jovan
Sclerosing Pneumocytoma: A Ten-Year Experience at a Western Balkan University Hospital
title Sclerosing Pneumocytoma: A Ten-Year Experience at a Western Balkan University Hospital
title_full Sclerosing Pneumocytoma: A Ten-Year Experience at a Western Balkan University Hospital
title_fullStr Sclerosing Pneumocytoma: A Ten-Year Experience at a Western Balkan University Hospital
title_full_unstemmed Sclerosing Pneumocytoma: A Ten-Year Experience at a Western Balkan University Hospital
title_short Sclerosing Pneumocytoma: A Ten-Year Experience at a Western Balkan University Hospital
title_sort sclerosing pneumocytoma: a ten-year experience at a western balkan university hospital
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409643/
https://www.ncbi.nlm.nih.gov/pubmed/30691016
http://dx.doi.org/10.3390/medicina55020027
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