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Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp.

The isolation and structural elucidation of a structurally new desertomycin, designated as desertomycin G (1), with strong antibiotic activity against several clinically relevant antibiotic resistant pathogens are described herein. This new natural product was obtained from cultures of the marine ac...

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Autores principales: Braña, Alfredo F., Sarmiento-Vizcaíno, Aida, Pérez-Victoria, Ignacio, Martín, Jesús, Otero, Luis, Palacios-Gutiérrez, Juan José, Fernández, Jonathan, Mohamedi, Yamina, Fontanil, Tania, Salmón, Marina, Cal, Santiago, Reyes, Fernando, García, Luis A., Blanco, Gloria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409695/
https://www.ncbi.nlm.nih.gov/pubmed/30759848
http://dx.doi.org/10.3390/md17020114
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author Braña, Alfredo F.
Sarmiento-Vizcaíno, Aida
Pérez-Victoria, Ignacio
Martín, Jesús
Otero, Luis
Palacios-Gutiérrez, Juan José
Fernández, Jonathan
Mohamedi, Yamina
Fontanil, Tania
Salmón, Marina
Cal, Santiago
Reyes, Fernando
García, Luis A.
Blanco, Gloria
author_facet Braña, Alfredo F.
Sarmiento-Vizcaíno, Aida
Pérez-Victoria, Ignacio
Martín, Jesús
Otero, Luis
Palacios-Gutiérrez, Juan José
Fernández, Jonathan
Mohamedi, Yamina
Fontanil, Tania
Salmón, Marina
Cal, Santiago
Reyes, Fernando
García, Luis A.
Blanco, Gloria
author_sort Braña, Alfredo F.
collection PubMed
description The isolation and structural elucidation of a structurally new desertomycin, designated as desertomycin G (1), with strong antibiotic activity against several clinically relevant antibiotic resistant pathogens are described herein. This new natural product was obtained from cultures of the marine actinomycete Streptomyces althioticus MSM3, isolated from samples of the intertidal seaweed Ulva sp. collected in the Cantabrian Sea (Northeast Atlantic Ocean). Particularly interesting is its strong antibiotic activity against Mycobacterium tuberculosis clinical isolates, resistant to antibiotics in clinical use. To the best of our knowledge, this is the first report on a member of the desertomycin family displaying such activity. Additionally, desertomycin G shows strong antibiotic activities against other relevant Gram-positive clinical pathogens such as Corynebacterium urealyticum, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecium, Enterococcus faecalis, and Clostridium perfringens. Desertomycin G also displays moderate antibiotic activity against relevant Gram-negative clinical pathogens such as Bacteroides fragilis, Haemophilus influenzae and Neisseria meningitidis. In addition, the compound affects viability of tumor cell lines, such as human breast adenocarcinoma (MCF-7) and colon carcinoma (DLD-1), but not normal mammary fibroblasts.
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spelling pubmed-64096952019-03-29 Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. Braña, Alfredo F. Sarmiento-Vizcaíno, Aida Pérez-Victoria, Ignacio Martín, Jesús Otero, Luis Palacios-Gutiérrez, Juan José Fernández, Jonathan Mohamedi, Yamina Fontanil, Tania Salmón, Marina Cal, Santiago Reyes, Fernando García, Luis A. Blanco, Gloria Mar Drugs Article The isolation and structural elucidation of a structurally new desertomycin, designated as desertomycin G (1), with strong antibiotic activity against several clinically relevant antibiotic resistant pathogens are described herein. This new natural product was obtained from cultures of the marine actinomycete Streptomyces althioticus MSM3, isolated from samples of the intertidal seaweed Ulva sp. collected in the Cantabrian Sea (Northeast Atlantic Ocean). Particularly interesting is its strong antibiotic activity against Mycobacterium tuberculosis clinical isolates, resistant to antibiotics in clinical use. To the best of our knowledge, this is the first report on a member of the desertomycin family displaying such activity. Additionally, desertomycin G shows strong antibiotic activities against other relevant Gram-positive clinical pathogens such as Corynebacterium urealyticum, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecium, Enterococcus faecalis, and Clostridium perfringens. Desertomycin G also displays moderate antibiotic activity against relevant Gram-negative clinical pathogens such as Bacteroides fragilis, Haemophilus influenzae and Neisseria meningitidis. In addition, the compound affects viability of tumor cell lines, such as human breast adenocarcinoma (MCF-7) and colon carcinoma (DLD-1), but not normal mammary fibroblasts. MDPI 2019-02-12 /pmc/articles/PMC6409695/ /pubmed/30759848 http://dx.doi.org/10.3390/md17020114 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Braña, Alfredo F.
Sarmiento-Vizcaíno, Aida
Pérez-Victoria, Ignacio
Martín, Jesús
Otero, Luis
Palacios-Gutiérrez, Juan José
Fernández, Jonathan
Mohamedi, Yamina
Fontanil, Tania
Salmón, Marina
Cal, Santiago
Reyes, Fernando
García, Luis A.
Blanco, Gloria
Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp.
title Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp.
title_full Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp.
title_fullStr Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp.
title_full_unstemmed Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp.
title_short Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp.
title_sort desertomycin g, a new antibiotic with activity against mycobacterium tuberculosis and human breast tumor cell lines produced by streptomyces althioticus msm3, isolated from the cantabrian sea intertidal macroalgae ulva sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409695/
https://www.ncbi.nlm.nih.gov/pubmed/30759848
http://dx.doi.org/10.3390/md17020114
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