Cargando…
A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita
In the present in vivo study, we provide a comparison of toxicological consequences induced by four different types of spherical nanoparticles (NPs)—silver nanoparticles (AgNPs, 40 ± 6 nm), nickel (NiNPs, 43 ± 6 nm), cobalt oxide (Co(3)O(4)NPs, 60 ± 6 nm), and chromium oxide (Cr(3)O(4)NPs, 50 ± 5 nm...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409703/ https://www.ncbi.nlm.nih.gov/pubmed/30823536 http://dx.doi.org/10.3390/nano9020309 |
_version_ | 1783402042695352320 |
---|---|
author | Kanwal, Zakia Raza, Muhammad Akram Manzoor, Farkhanda Riaz, Saira Jabeen, Ghazala Fatima, Shafaq Naseem, Shahzad |
author_facet | Kanwal, Zakia Raza, Muhammad Akram Manzoor, Farkhanda Riaz, Saira Jabeen, Ghazala Fatima, Shafaq Naseem, Shahzad |
author_sort | Kanwal, Zakia |
collection | PubMed |
description | In the present in vivo study, we provide a comparison of toxicological consequences induced by four different types of spherical nanoparticles (NPs)—silver nanoparticles (AgNPs, 40 ± 6 nm), nickel (NiNPs, 43 ± 6 nm), cobalt oxide (Co(3)O(4)NPs, 60 ± 6 nm), and chromium oxide (Cr(3)O(4)NPs, 50 ± 5 nm)—on freshwater fish Labeo rohita. Fish were exposed to NPs (25 mg/L) for 21 days. We observed a NPs type-dependent toxicity in fish. An altered behavior showing signs of stress and a substantial reduction in total leukocyte count was noticed in all NP-treated groups. A low total erythrocyte count in all NP-treated fish except for Co(3)O(4)NPs was discerned while a low survival rate in the case of Cr(3)O(4)NP-treated fish was observed. A significant decrease in growth and hemoglobin were noticed in NiNP- and Cr(3)O(4)NP-treated fish. A considerable total protein elevation was detected in NiNP-, Co(3)O(4)NP-, and Cr(3)O(4)NP-treated groups. An upgrading in albumin level was witnessed in Co(3)O(4)NP- and Cr(3)O(4)NP-treated groups while a high level of globulin was noted in NiNP- and Co(3)O(4)NP-exposed groups. In all NP-treated groups, a depleted activity of antioxidative enzymes and pathological lesions in liver and kidney were noticed. |
format | Online Article Text |
id | pubmed-6409703 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64097032019-03-11 A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita Kanwal, Zakia Raza, Muhammad Akram Manzoor, Farkhanda Riaz, Saira Jabeen, Ghazala Fatima, Shafaq Naseem, Shahzad Nanomaterials (Basel) Article In the present in vivo study, we provide a comparison of toxicological consequences induced by four different types of spherical nanoparticles (NPs)—silver nanoparticles (AgNPs, 40 ± 6 nm), nickel (NiNPs, 43 ± 6 nm), cobalt oxide (Co(3)O(4)NPs, 60 ± 6 nm), and chromium oxide (Cr(3)O(4)NPs, 50 ± 5 nm)—on freshwater fish Labeo rohita. Fish were exposed to NPs (25 mg/L) for 21 days. We observed a NPs type-dependent toxicity in fish. An altered behavior showing signs of stress and a substantial reduction in total leukocyte count was noticed in all NP-treated groups. A low total erythrocyte count in all NP-treated fish except for Co(3)O(4)NPs was discerned while a low survival rate in the case of Cr(3)O(4)NP-treated fish was observed. A significant decrease in growth and hemoglobin were noticed in NiNP- and Cr(3)O(4)NP-treated fish. A considerable total protein elevation was detected in NiNP-, Co(3)O(4)NP-, and Cr(3)O(4)NP-treated groups. An upgrading in albumin level was witnessed in Co(3)O(4)NP- and Cr(3)O(4)NP-treated groups while a high level of globulin was noted in NiNP- and Co(3)O(4)NP-exposed groups. In all NP-treated groups, a depleted activity of antioxidative enzymes and pathological lesions in liver and kidney were noticed. MDPI 2019-02-25 /pmc/articles/PMC6409703/ /pubmed/30823536 http://dx.doi.org/10.3390/nano9020309 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kanwal, Zakia Raza, Muhammad Akram Manzoor, Farkhanda Riaz, Saira Jabeen, Ghazala Fatima, Shafaq Naseem, Shahzad A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita |
title | A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita |
title_full | A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita |
title_fullStr | A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita |
title_full_unstemmed | A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita |
title_short | A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in Labeo rohita |
title_sort | comparative assessment of nanotoxicity induced by metal (silver, nickel) and metal oxide (cobalt, chromium) nanoparticles in labeo rohita |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409703/ https://www.ncbi.nlm.nih.gov/pubmed/30823536 http://dx.doi.org/10.3390/nano9020309 |
work_keys_str_mv | AT kanwalzakia acomparativeassessmentofnanotoxicityinducedbymetalsilvernickelandmetaloxidecobaltchromiumnanoparticlesinlabeorohita AT razamuhammadakram acomparativeassessmentofnanotoxicityinducedbymetalsilvernickelandmetaloxidecobaltchromiumnanoparticlesinlabeorohita AT manzoorfarkhanda acomparativeassessmentofnanotoxicityinducedbymetalsilvernickelandmetaloxidecobaltchromiumnanoparticlesinlabeorohita AT riazsaira acomparativeassessmentofnanotoxicityinducedbymetalsilvernickelandmetaloxidecobaltchromiumnanoparticlesinlabeorohita AT jabeenghazala acomparativeassessmentofnanotoxicityinducedbymetalsilvernickelandmetaloxidecobaltchromiumnanoparticlesinlabeorohita AT fatimashafaq acomparativeassessmentofnanotoxicityinducedbymetalsilvernickelandmetaloxidecobaltchromiumnanoparticlesinlabeorohita AT naseemshahzad acomparativeassessmentofnanotoxicityinducedbymetalsilvernickelandmetaloxidecobaltchromiumnanoparticlesinlabeorohita AT kanwalzakia comparativeassessmentofnanotoxicityinducedbymetalsilvernickelandmetaloxidecobaltchromiumnanoparticlesinlabeorohita AT razamuhammadakram comparativeassessmentofnanotoxicityinducedbymetalsilvernickelandmetaloxidecobaltchromiumnanoparticlesinlabeorohita AT manzoorfarkhanda comparativeassessmentofnanotoxicityinducedbymetalsilvernickelandmetaloxidecobaltchromiumnanoparticlesinlabeorohita AT riazsaira comparativeassessmentofnanotoxicityinducedbymetalsilvernickelandmetaloxidecobaltchromiumnanoparticlesinlabeorohita AT jabeenghazala comparativeassessmentofnanotoxicityinducedbymetalsilvernickelandmetaloxidecobaltchromiumnanoparticlesinlabeorohita AT fatimashafaq comparativeassessmentofnanotoxicityinducedbymetalsilvernickelandmetaloxidecobaltchromiumnanoparticlesinlabeorohita AT naseemshahzad comparativeassessmentofnanotoxicityinducedbymetalsilvernickelandmetaloxidecobaltchromiumnanoparticlesinlabeorohita |