A Cell-Level Systems PK-PD Model to Characterize In Vivo Efficacy of ADCs

Here, we have presented the development of a systems pharmacokinetics-pharmacodynamics (PK-PD) model for antibody-drug conjugates (ADCs), which uses intracellular target occupancy to drive in-vivo efficacy. The model is built based on PK and efficacy data generated using Trastuzumab-Valine-Citrullin...

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Detalles Bibliográficos
Autores principales: Singh, Aman P., Guo, Leiming, Verma, Ashwni, Wong, Gloria Gao-Li, Shah, Dhaval K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409735/
https://www.ncbi.nlm.nih.gov/pubmed/30823607
http://dx.doi.org/10.3390/pharmaceutics11020098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409735/
https://www.ncbi.nlm.nih.gov/pubmed/30823607
http://dx.doi.org/10.3390/pharmaceutics11020098

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