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Metabolic Reprogramming of the Host Cell by Human Adenovirus Infection

Viruses are obligate intracellular parasites that alter many cellular processes to create an environment optimal for viral replication. Reprogramming of cellular metabolism is an important, yet underappreciated feature of many viral infections, as this ensures that the energy and substrates required...

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Autores principales: Prusinkiewicz, Martin A., Mymryk, Joe S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409786/
https://www.ncbi.nlm.nih.gov/pubmed/30744016
http://dx.doi.org/10.3390/v11020141
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author Prusinkiewicz, Martin A.
Mymryk, Joe S.
author_facet Prusinkiewicz, Martin A.
Mymryk, Joe S.
author_sort Prusinkiewicz, Martin A.
collection PubMed
description Viruses are obligate intracellular parasites that alter many cellular processes to create an environment optimal for viral replication. Reprogramming of cellular metabolism is an important, yet underappreciated feature of many viral infections, as this ensures that the energy and substrates required for viral replication are available in abundance. Human adenovirus (HAdV), which is the focus of this review, is a small DNA tumor virus that reprograms cellular metabolism in a variety of ways. It is well known that HAdV infection increases glucose uptake and fermentation to lactate in a manner resembling the Warburg effect observed in many cancer cells. However, HAdV infection induces many other metabolic changes. In this review, we integrate the findings from a variety of proteomic and transcriptomic studies to understand the subtleties of metabolite and metabolic pathway control during HAdV infection. We review how the E4ORF1 protein of HAdV enacts some of these changes and summarize evidence for reprogramming of cellular metabolism by the viral E1A protein. Therapies targeting altered metabolism are emerging as cancer treatments, and similar targeting of aberrant components of virally reprogrammed metabolism could have clinical antiviral applications.
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spelling pubmed-64097862019-04-01 Metabolic Reprogramming of the Host Cell by Human Adenovirus Infection Prusinkiewicz, Martin A. Mymryk, Joe S. Viruses Review Viruses are obligate intracellular parasites that alter many cellular processes to create an environment optimal for viral replication. Reprogramming of cellular metabolism is an important, yet underappreciated feature of many viral infections, as this ensures that the energy and substrates required for viral replication are available in abundance. Human adenovirus (HAdV), which is the focus of this review, is a small DNA tumor virus that reprograms cellular metabolism in a variety of ways. It is well known that HAdV infection increases glucose uptake and fermentation to lactate in a manner resembling the Warburg effect observed in many cancer cells. However, HAdV infection induces many other metabolic changes. In this review, we integrate the findings from a variety of proteomic and transcriptomic studies to understand the subtleties of metabolite and metabolic pathway control during HAdV infection. We review how the E4ORF1 protein of HAdV enacts some of these changes and summarize evidence for reprogramming of cellular metabolism by the viral E1A protein. Therapies targeting altered metabolism are emerging as cancer treatments, and similar targeting of aberrant components of virally reprogrammed metabolism could have clinical antiviral applications. MDPI 2019-02-08 /pmc/articles/PMC6409786/ /pubmed/30744016 http://dx.doi.org/10.3390/v11020141 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Prusinkiewicz, Martin A.
Mymryk, Joe S.
Metabolic Reprogramming of the Host Cell by Human Adenovirus Infection
title Metabolic Reprogramming of the Host Cell by Human Adenovirus Infection
title_full Metabolic Reprogramming of the Host Cell by Human Adenovirus Infection
title_fullStr Metabolic Reprogramming of the Host Cell by Human Adenovirus Infection
title_full_unstemmed Metabolic Reprogramming of the Host Cell by Human Adenovirus Infection
title_short Metabolic Reprogramming of the Host Cell by Human Adenovirus Infection
title_sort metabolic reprogramming of the host cell by human adenovirus infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409786/
https://www.ncbi.nlm.nih.gov/pubmed/30744016
http://dx.doi.org/10.3390/v11020141
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