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Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease

Lyme disease is a multisystem tick-borne transmissive disease with heterogeneous manifestations, frequently making the diagnosis difficult in clinical practice. Herein, we report a case of a 43-year-old female patient who presented with generalized lymphadenopathy requiring a further diagnostic eval...

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Autores principales: Smiyan, Svitlana, Galaychuk, Igor, Zhulkevych, Igor, Nykolyuk, Volodymyr, Komorovsky, Roman, Gusak, Sofiya, Bilozetsky, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409830/
https://www.ncbi.nlm.nih.gov/pubmed/30858633
http://dx.doi.org/10.5114/reum.2019.83242
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author Smiyan, Svitlana
Galaychuk, Igor
Zhulkevych, Igor
Nykolyuk, Volodymyr
Komorovsky, Roman
Gusak, Sofiya
Bilozetsky, Ivan
author_facet Smiyan, Svitlana
Galaychuk, Igor
Zhulkevych, Igor
Nykolyuk, Volodymyr
Komorovsky, Roman
Gusak, Sofiya
Bilozetsky, Ivan
author_sort Smiyan, Svitlana
collection PubMed
description Lyme disease is a multisystem tick-borne transmissive disease with heterogeneous manifestations, frequently making the diagnosis difficult in clinical practice. Herein, we report a case of a 43-year-old female patient who presented with generalized lymphadenopathy requiring a further diagnostic evaluation towards lymphoma. The patient also had clinical signs of Sjögren’s syndrome. Lymph node excision with subsequent histological and immunohistochemical studies were performed. While light microscopy findings were suspicious for lymphoma, immunohistochemistry results were consistent with cortical and paracortical lymph node hyperplasia with no evidence of lymphoproliferative disorder. Further laboratory testing confirmed the presence of Lyme borreliosis. Effectiveness of the administered antibiotic therapy confirmed Borrelia burgdorferi infection. Interrelationships between Sjögren’s syndrome, lymphadenopathy and Lyme disease are discussed.
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spelling pubmed-64098302019-03-11 Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease Smiyan, Svitlana Galaychuk, Igor Zhulkevych, Igor Nykolyuk, Volodymyr Komorovsky, Roman Gusak, Sofiya Bilozetsky, Ivan Reumatologia Case Report Lyme disease is a multisystem tick-borne transmissive disease with heterogeneous manifestations, frequently making the diagnosis difficult in clinical practice. Herein, we report a case of a 43-year-old female patient who presented with generalized lymphadenopathy requiring a further diagnostic evaluation towards lymphoma. The patient also had clinical signs of Sjögren’s syndrome. Lymph node excision with subsequent histological and immunohistochemical studies were performed. While light microscopy findings were suspicious for lymphoma, immunohistochemistry results were consistent with cortical and paracortical lymph node hyperplasia with no evidence of lymphoproliferative disorder. Further laboratory testing confirmed the presence of Lyme borreliosis. Effectiveness of the administered antibiotic therapy confirmed Borrelia burgdorferi infection. Interrelationships between Sjögren’s syndrome, lymphadenopathy and Lyme disease are discussed. Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie 2019-02-28 2019 /pmc/articles/PMC6409830/ /pubmed/30858633 http://dx.doi.org/10.5114/reum.2019.83242 Text en Copyright: © 2019 Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Case Report
Smiyan, Svitlana
Galaychuk, Igor
Zhulkevych, Igor
Nykolyuk, Volodymyr
Komorovsky, Roman
Gusak, Sofiya
Bilozetsky, Ivan
Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease
title Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease
title_full Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease
title_fullStr Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease
title_full_unstemmed Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease
title_short Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme disease
title_sort sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of lyme disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409830/
https://www.ncbi.nlm.nih.gov/pubmed/30858633
http://dx.doi.org/10.5114/reum.2019.83242
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