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Usutu Virus Isolated from Rodents in Senegal

Usutu virus (USUV) is a Culex-associated mosquito-borne flavivirus of the Flaviviridae family. Since its discovery in 1959, the virus has been isolated from birds, arthropods and humans in Europe and Africa. An increasing number of Usutu virus infections in humans with neurological presentations hav...

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Autores principales: Diagne, Moussa Moïse, Ndione, Marie Henriette Dior, Di Paola, Nicholas, Fall, Gamou, Bedekelabou, André Pouwedeou, Sembène, Pape Mbacké, Faye, Ousmane, Zanotto, Paolo Marinho de Andrade, Sall, Amadou Alpha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409855/
https://www.ncbi.nlm.nih.gov/pubmed/30795524
http://dx.doi.org/10.3390/v11020181
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author Diagne, Moussa Moïse
Ndione, Marie Henriette Dior
Di Paola, Nicholas
Fall, Gamou
Bedekelabou, André Pouwedeou
Sembène, Pape Mbacké
Faye, Ousmane
Zanotto, Paolo Marinho de Andrade
Sall, Amadou Alpha
author_facet Diagne, Moussa Moïse
Ndione, Marie Henriette Dior
Di Paola, Nicholas
Fall, Gamou
Bedekelabou, André Pouwedeou
Sembène, Pape Mbacké
Faye, Ousmane
Zanotto, Paolo Marinho de Andrade
Sall, Amadou Alpha
author_sort Diagne, Moussa Moïse
collection PubMed
description Usutu virus (USUV) is a Culex-associated mosquito-borne flavivirus of the Flaviviridae family. Since its discovery in 1959, the virus has been isolated from birds, arthropods and humans in Europe and Africa. An increasing number of Usutu virus infections in humans with neurological presentations have been reported. Recently, the virus has been detected in bats and horses, which deviates from the currently proposed enzootic cycle of USUV involving several different avian and mosquito species. Despite this increasing number of viral detections in different mammalian hosts, the existence of a non-avian reservoir remains unresolved. In Kedougou, a tropical region in the southeast corner of Senegal, Usutu virus was detected, isolated and sequenced from five asymptomatic small mammals: Two different rodent species and a single species of shrew. Additional molecular characterization and in vivo growth dynamics showed that these rodents/shrew-derived viruses are closely related to the reference strain (accession number: AF013412) and are as pathogenic as other characterized strains associated with neurological invasions in human. This is the first evidence of Usutu virus isolation from rodents or shrews. Our findings emphasize the need to consider a closer monitoring of terrestrial small mammals in future active surveillance, public health, and epidemiological efforts in response to USUV in both Africa and Europe.
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spelling pubmed-64098552019-04-01 Usutu Virus Isolated from Rodents in Senegal Diagne, Moussa Moïse Ndione, Marie Henriette Dior Di Paola, Nicholas Fall, Gamou Bedekelabou, André Pouwedeou Sembène, Pape Mbacké Faye, Ousmane Zanotto, Paolo Marinho de Andrade Sall, Amadou Alpha Viruses Article Usutu virus (USUV) is a Culex-associated mosquito-borne flavivirus of the Flaviviridae family. Since its discovery in 1959, the virus has been isolated from birds, arthropods and humans in Europe and Africa. An increasing number of Usutu virus infections in humans with neurological presentations have been reported. Recently, the virus has been detected in bats and horses, which deviates from the currently proposed enzootic cycle of USUV involving several different avian and mosquito species. Despite this increasing number of viral detections in different mammalian hosts, the existence of a non-avian reservoir remains unresolved. In Kedougou, a tropical region in the southeast corner of Senegal, Usutu virus was detected, isolated and sequenced from five asymptomatic small mammals: Two different rodent species and a single species of shrew. Additional molecular characterization and in vivo growth dynamics showed that these rodents/shrew-derived viruses are closely related to the reference strain (accession number: AF013412) and are as pathogenic as other characterized strains associated with neurological invasions in human. This is the first evidence of Usutu virus isolation from rodents or shrews. Our findings emphasize the need to consider a closer monitoring of terrestrial small mammals in future active surveillance, public health, and epidemiological efforts in response to USUV in both Africa and Europe. MDPI 2019-02-21 /pmc/articles/PMC6409855/ /pubmed/30795524 http://dx.doi.org/10.3390/v11020181 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Diagne, Moussa Moïse
Ndione, Marie Henriette Dior
Di Paola, Nicholas
Fall, Gamou
Bedekelabou, André Pouwedeou
Sembène, Pape Mbacké
Faye, Ousmane
Zanotto, Paolo Marinho de Andrade
Sall, Amadou Alpha
Usutu Virus Isolated from Rodents in Senegal
title Usutu Virus Isolated from Rodents in Senegal
title_full Usutu Virus Isolated from Rodents in Senegal
title_fullStr Usutu Virus Isolated from Rodents in Senegal
title_full_unstemmed Usutu Virus Isolated from Rodents in Senegal
title_short Usutu Virus Isolated from Rodents in Senegal
title_sort usutu virus isolated from rodents in senegal
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409855/
https://www.ncbi.nlm.nih.gov/pubmed/30795524
http://dx.doi.org/10.3390/v11020181
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