Staphylococcus aureus: an underestimated factor in the pathogenesis of atopic dermatitis?

Atopic dermatitis is a common, recurrent pruritic dermatosis with a complex pathogenesis. It has been associated with disordered patterns of immunological response and impaired epithelial barrier integrity. These features predispose the patients to robust colonization of skin lesions by Staphylococc...

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Detalles Bibliográficos
Autores principales: Blicharz, Leszek, Rudnicka, Lidia, Samochocki, Zbigniew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2019
Materias:
Review Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409874/
https://www.ncbi.nlm.nih.gov/pubmed/30858773
http://dx.doi.org/10.5114/ada.2019.82821
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author Blicharz, Leszek
Rudnicka, Lidia
Samochocki, Zbigniew
author_facet Blicharz, Leszek
Rudnicka, Lidia
Samochocki, Zbigniew
author_sort Blicharz, Leszek
collection PubMed
description Atopic dermatitis is a common, recurrent pruritic dermatosis with a complex pathogenesis. It has been associated with disordered patterns of immunological response and impaired epithelial barrier integrity. These features predispose the patients to robust colonization of skin lesions by Staphylococcus aureus. Virulence factors of S. aureus (e.g. superantigens, α- and δ-toxin, protein A) have been shown to exacerbate and perpetuate the course of atopic dermatitis. Novel therapeutic options with potential for restoring natural microbiome composition are being elaborated and may enter clinical practice in the future.
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spelling pubmed-64098742019-03-11 Staphylococcus aureus: an underestimated factor in the pathogenesis of atopic dermatitis? Blicharz, Leszek Rudnicka, Lidia Samochocki, Zbigniew Postepy Dermatol Alergol Review Paper Atopic dermatitis is a common, recurrent pruritic dermatosis with a complex pathogenesis. It has been associated with disordered patterns of immunological response and impaired epithelial barrier integrity. These features predispose the patients to robust colonization of skin lesions by Staphylococcus aureus. Virulence factors of S. aureus (e.g. superantigens, α- and δ-toxin, protein A) have been shown to exacerbate and perpetuate the course of atopic dermatitis. Novel therapeutic options with potential for restoring natural microbiome composition are being elaborated and may enter clinical practice in the future. Termedia Publishing House 2019-02-22 2019-02 /pmc/articles/PMC6409874/ /pubmed/30858773 http://dx.doi.org/10.5114/ada.2019.82821 Text en Copyright: © 2019 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Review Paper
Blicharz, Leszek
Rudnicka, Lidia
Samochocki, Zbigniew
Staphylococcus aureus: an underestimated factor in the pathogenesis of atopic dermatitis?
title Staphylococcus aureus: an underestimated factor in the pathogenesis of atopic dermatitis?
title_full Staphylococcus aureus: an underestimated factor in the pathogenesis of atopic dermatitis?
title_fullStr Staphylococcus aureus: an underestimated factor in the pathogenesis of atopic dermatitis?
title_full_unstemmed Staphylococcus aureus: an underestimated factor in the pathogenesis of atopic dermatitis?
title_short Staphylococcus aureus: an underestimated factor in the pathogenesis of atopic dermatitis?
title_sort staphylococcus aureus: an underestimated factor in the pathogenesis of atopic dermatitis?
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409874/
https://www.ncbi.nlm.nih.gov/pubmed/30858773
http://dx.doi.org/10.5114/ada.2019.82821
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