Botulinum Neurotoxin Light Chains Expressed by Defective Herpes Simplex Virus Type-1 Vectors Cleave SNARE Proteins and Inhibit CGRP Release in Rat Sensory Neurons

A set of herpes simplex virus type 1 (HSV-1) amplicon vectors expressing the light chains (LC) of botulinum neurotoxins (BoNT) A, B, C, D, E and F was constructed. Their properties have been assessed in primary cultures of rat embryonic dorsal root ganglia (DRG) neurons, and in organotypic cultures...

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Detalles Bibliográficos
Autores principales: Joussain, Charles, Le Coz, Olivier, Pichugin, Andrey, Marconi, Peggy, Lim, Filip, Sicurella, Mariaconcetta, Salonia, Andrea, Montorsi, Francesco, Wandosell, Francisco, Foster, Keith, Giuliano, François, Epstein, Alberto L., Aranda Muñoz, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409900/
https://www.ncbi.nlm.nih.gov/pubmed/30791373
http://dx.doi.org/10.3390/toxins11020123

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