New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens

A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known co...

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Detalles Bibliográficos
Autores principales: Ebada, Sherif S., Müller, Werner E. G., Lin, Wenhan, Proksch, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409940/
https://www.ncbi.nlm.nih.gov/pubmed/30736370
http://dx.doi.org/10.3390/md17020100
Descripción
Sumario:A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambiguously elucidated based on HRESIMS and exhaustive 1D and 2D NMR spectral analysis as well as a comparison of their NMR data with those of jasplakinolide (1). The isolated jasplakinolides inhibited the growth of mouse lymphoma (L5178Y) cells in vitro with IC(50) values in the low micromolar to nanomolar range.

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