New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens

A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known co...

Descripción completa

Detalles Bibliográficos
Autores principales: Ebada, Sherif S., Müller, Werner E. G., Lin, Wenhan, Proksch, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409940/
https://www.ncbi.nlm.nih.gov/pubmed/30736370
http://dx.doi.org/10.3390/md17020100
_version_ 1783402109780099072
author Ebada, Sherif S.
Müller, Werner E. G.
Lin, Wenhan
Proksch, Peter
author_facet Ebada, Sherif S.
Müller, Werner E. G.
Lin, Wenhan
Proksch, Peter
author_sort Ebada, Sherif S.
collection PubMed
description A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambiguously elucidated based on HRESIMS and exhaustive 1D and 2D NMR spectral analysis as well as a comparison of their NMR data with those of jasplakinolide (1). The isolated jasplakinolides inhibited the growth of mouse lymphoma (L5178Y) cells in vitro with IC(50) values in the low micromolar to nanomolar range.
format Online
Article
Text
id pubmed-6409940
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-64099402019-03-29 New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens Ebada, Sherif S. Müller, Werner E. G. Lin, Wenhan Proksch, Peter Mar Drugs Article A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambiguously elucidated based on HRESIMS and exhaustive 1D and 2D NMR spectral analysis as well as a comparison of their NMR data with those of jasplakinolide (1). The isolated jasplakinolides inhibited the growth of mouse lymphoma (L5178Y) cells in vitro with IC(50) values in the low micromolar to nanomolar range. MDPI 2019-02-06 /pmc/articles/PMC6409940/ /pubmed/30736370 http://dx.doi.org/10.3390/md17020100 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ebada, Sherif S.
Müller, Werner E. G.
Lin, Wenhan
Proksch, Peter
New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens
title New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens
title_full New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens
title_fullStr New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens
title_full_unstemmed New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens
title_short New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens
title_sort new acyclic cytotoxic jasplakinolide derivative from the marine sponge jaspis splendens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409940/
https://www.ncbi.nlm.nih.gov/pubmed/30736370
http://dx.doi.org/10.3390/md17020100
work_keys_str_mv AT ebadasherifs newacycliccytotoxicjasplakinolidederivativefromthemarinespongejaspissplendens
AT mullerwernereg newacycliccytotoxicjasplakinolidederivativefromthemarinespongejaspissplendens
AT linwenhan newacycliccytotoxicjasplakinolidederivativefromthemarinespongejaspissplendens
AT prokschpeter newacycliccytotoxicjasplakinolidederivativefromthemarinespongejaspissplendens

Ejemplares similares