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Comparison of 30-Day MACE between Immediate versus Staged Complete Revascularization in Acute Myocardial Infarction with Multivessel Disease, and the Effect of Coronary Lesion Complexity
Background and objective: In patients with acute myocardial infarction and multivessel disease, the timing of intervention to non-culprit lesions is still a matter of debate, especially in patients without shock. This study aimed to compare the effect of multivessel intervention, performed at index...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410006/ https://www.ncbi.nlm.nih.gov/pubmed/30781429 http://dx.doi.org/10.3390/medicina55020051 |
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author | Doğan, Cem Bayram, Zübeyde Çap, Murat Özkalaycı, Flora Unkun, Tuba Erdoğan, Emrah Uslu, Abdulkadir Acar, Rezzan Deniz Guvendi, Busra Akbal, Özgur Yaşar Karagöz, Ali Hakgor, Aykun Karaduman, Ahmet Uysal, Samet Aykan, Ahmet Kaymaz, Cihangir Özdemir, Nihal |
author_facet | Doğan, Cem Bayram, Zübeyde Çap, Murat Özkalaycı, Flora Unkun, Tuba Erdoğan, Emrah Uslu, Abdulkadir Acar, Rezzan Deniz Guvendi, Busra Akbal, Özgur Yaşar Karagöz, Ali Hakgor, Aykun Karaduman, Ahmet Uysal, Samet Aykan, Ahmet Kaymaz, Cihangir Özdemir, Nihal |
author_sort | Doğan, Cem |
collection | PubMed |
description | Background and objective: In patients with acute myocardial infarction and multivessel disease, the timing of intervention to non-culprit lesions is still a matter of debate, especially in patients without shock. This study aimed to compare the effect of multivessel intervention, performed at index percutaneous coronary intervention (PCI) (MVI-I) or index hospitalization (MVI-S), on the 30-day results of acute myocardial infarction (AMI), and to investigate the effect of coronary lesion complexity assessed by the Syntax (Sx) score on the timing of multivessel intervention. Materials and methods: We enrolled 180 patients with MVI-I, and 425 patients with MVI-S. The major adverse cardiovascular events (MACE) for this study were identified as mortality, nonfatal myocardial infarction, nonfatal stroke, acute heart failure, ischemia driven revascularization, major bleeding, and acute renal failure developed within 30 days. Results: The unadjusted MACE rates at 30 days were 11.2% and 5% among those who underwent MVI-I and MVI-S, respectively (OR 3.02; 95% confidence interval (CI) 1.51–6.02; p = 0.002). Associations were statistically significant after adjusting for covariates in the penalized multivariable model (adjusted OR 2.06; 95%CI 1.02–4.18; p = 0.043), propensity score adjusted multivariable model (adjusted OR 2.46; 95%CI 1.19–5.07; p = 0.015), and IPW (adjusted OR 2.11; 95%CI 1.28–3.47; p = 0.041). We found that the Syntax score of lesions did not affect the results. Conclusion: MVI-S was associated with a lower incidence of major adverse cardiovascular events within 30 days after discharge. |
format | Online Article Text |
id | pubmed-6410006 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64100062019-03-25 Comparison of 30-Day MACE between Immediate versus Staged Complete Revascularization in Acute Myocardial Infarction with Multivessel Disease, and the Effect of Coronary Lesion Complexity Doğan, Cem Bayram, Zübeyde Çap, Murat Özkalaycı, Flora Unkun, Tuba Erdoğan, Emrah Uslu, Abdulkadir Acar, Rezzan Deniz Guvendi, Busra Akbal, Özgur Yaşar Karagöz, Ali Hakgor, Aykun Karaduman, Ahmet Uysal, Samet Aykan, Ahmet Kaymaz, Cihangir Özdemir, Nihal Medicina (Kaunas) Article Background and objective: In patients with acute myocardial infarction and multivessel disease, the timing of intervention to non-culprit lesions is still a matter of debate, especially in patients without shock. This study aimed to compare the effect of multivessel intervention, performed at index percutaneous coronary intervention (PCI) (MVI-I) or index hospitalization (MVI-S), on the 30-day results of acute myocardial infarction (AMI), and to investigate the effect of coronary lesion complexity assessed by the Syntax (Sx) score on the timing of multivessel intervention. Materials and methods: We enrolled 180 patients with MVI-I, and 425 patients with MVI-S. The major adverse cardiovascular events (MACE) for this study were identified as mortality, nonfatal myocardial infarction, nonfatal stroke, acute heart failure, ischemia driven revascularization, major bleeding, and acute renal failure developed within 30 days. Results: The unadjusted MACE rates at 30 days were 11.2% and 5% among those who underwent MVI-I and MVI-S, respectively (OR 3.02; 95% confidence interval (CI) 1.51–6.02; p = 0.002). Associations were statistically significant after adjusting for covariates in the penalized multivariable model (adjusted OR 2.06; 95%CI 1.02–4.18; p = 0.043), propensity score adjusted multivariable model (adjusted OR 2.46; 95%CI 1.19–5.07; p = 0.015), and IPW (adjusted OR 2.11; 95%CI 1.28–3.47; p = 0.041). We found that the Syntax score of lesions did not affect the results. Conclusion: MVI-S was associated with a lower incidence of major adverse cardiovascular events within 30 days after discharge. MDPI 2019-02-15 /pmc/articles/PMC6410006/ /pubmed/30781429 http://dx.doi.org/10.3390/medicina55020051 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Doğan, Cem Bayram, Zübeyde Çap, Murat Özkalaycı, Flora Unkun, Tuba Erdoğan, Emrah Uslu, Abdulkadir Acar, Rezzan Deniz Guvendi, Busra Akbal, Özgur Yaşar Karagöz, Ali Hakgor, Aykun Karaduman, Ahmet Uysal, Samet Aykan, Ahmet Kaymaz, Cihangir Özdemir, Nihal Comparison of 30-Day MACE between Immediate versus Staged Complete Revascularization in Acute Myocardial Infarction with Multivessel Disease, and the Effect of Coronary Lesion Complexity |
title | Comparison of 30-Day MACE between Immediate versus Staged Complete Revascularization in Acute Myocardial Infarction with Multivessel Disease, and the Effect of Coronary Lesion Complexity |
title_full | Comparison of 30-Day MACE between Immediate versus Staged Complete Revascularization in Acute Myocardial Infarction with Multivessel Disease, and the Effect of Coronary Lesion Complexity |
title_fullStr | Comparison of 30-Day MACE between Immediate versus Staged Complete Revascularization in Acute Myocardial Infarction with Multivessel Disease, and the Effect of Coronary Lesion Complexity |
title_full_unstemmed | Comparison of 30-Day MACE between Immediate versus Staged Complete Revascularization in Acute Myocardial Infarction with Multivessel Disease, and the Effect of Coronary Lesion Complexity |
title_short | Comparison of 30-Day MACE between Immediate versus Staged Complete Revascularization in Acute Myocardial Infarction with Multivessel Disease, and the Effect of Coronary Lesion Complexity |
title_sort | comparison of 30-day mace between immediate versus staged complete revascularization in acute myocardial infarction with multivessel disease, and the effect of coronary lesion complexity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410006/ https://www.ncbi.nlm.nih.gov/pubmed/30781429 http://dx.doi.org/10.3390/medicina55020051 |
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