Checkpoint inhibition of PD-L1 and CTLA-4 in a child with refractory acute leukemia

Children with multiple relapsed or refractory leukemia have dismal survival. Research has identified engagement of immune checkpoint receptors (e.g., PD-1, PD-L1 and CTLA-4) as a mechanism for treatment resistance. For adult cancer, inhibitors of PD-1 (nivolumab) and CTLA-4 (ipilimumab) have shown p...

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Detalles Bibliográficos
Autores principales: Broglie, Larisa, Gershan, Jill, Burke, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410023/
https://www.ncbi.nlm.nih.gov/pubmed/30863527
http://dx.doi.org/10.2217/ijh-2018-0009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410023/
https://www.ncbi.nlm.nih.gov/pubmed/30863527
http://dx.doi.org/10.2217/ijh-2018-0009

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