Novel Antimicrobial Indolepyrazines A and B from the Marine-Associated Acinetobacter sp. ZZ1275

Two new alkaloids indolepyrazines A (1) and B (2) were isolated from the marine-derived Acinetobacter sp. ZZ1275. Their structures were elucidated through extensive nuclear magnetic resonance (NMR) spectroscopic analyses, high resolution electrospray ionization mass spectroscopy (HRESIMS) data, and...

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Autores principales: Anjum, Komal, Kaleem, Sidra, Yi, Wenwen, Zheng, Guowan, Lian, Xiaoyuan, Zhang, Zhizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410138/
https://www.ncbi.nlm.nih.gov/pubmed/30717135
http://dx.doi.org/10.3390/md17020089
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author Anjum, Komal
Kaleem, Sidra
Yi, Wenwen
Zheng, Guowan
Lian, Xiaoyuan
Zhang, Zhizhen
author_facet Anjum, Komal
Kaleem, Sidra
Yi, Wenwen
Zheng, Guowan
Lian, Xiaoyuan
Zhang, Zhizhen
author_sort Anjum, Komal
collection PubMed
description Two new alkaloids indolepyrazines A (1) and B (2) were isolated from the marine-derived Acinetobacter sp. ZZ1275. Their structures were elucidated through extensive nuclear magnetic resonance (NMR) spectroscopic analyses, high resolution electrospray ionization mass spectroscopy (HRESIMS) data, and electronic circular dichroism (ECD) calculation. Indolepyrazine A represents the first example of alkaloids with an indole-pyrazine-oxindole skeleton. Both 1 and 2 showed antimicrobial activities against methicillin-resistant Staphylococcus aureus, Escherichia coli, and Candida albicans with minimum inhibitory concentration (MIC) values of 12 μg/mL, 8–10 μg/mL, and 12–14 μg/mL, respectively.
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spelling pubmed-64101382019-03-29 Novel Antimicrobial Indolepyrazines A and B from the Marine-Associated Acinetobacter sp. ZZ1275 Anjum, Komal Kaleem, Sidra Yi, Wenwen Zheng, Guowan Lian, Xiaoyuan Zhang, Zhizhen Mar Drugs Communication Two new alkaloids indolepyrazines A (1) and B (2) were isolated from the marine-derived Acinetobacter sp. ZZ1275. Their structures were elucidated through extensive nuclear magnetic resonance (NMR) spectroscopic analyses, high resolution electrospray ionization mass spectroscopy (HRESIMS) data, and electronic circular dichroism (ECD) calculation. Indolepyrazine A represents the first example of alkaloids with an indole-pyrazine-oxindole skeleton. Both 1 and 2 showed antimicrobial activities against methicillin-resistant Staphylococcus aureus, Escherichia coli, and Candida albicans with minimum inhibitory concentration (MIC) values of 12 μg/mL, 8–10 μg/mL, and 12–14 μg/mL, respectively. MDPI 2019-02-01 /pmc/articles/PMC6410138/ /pubmed/30717135 http://dx.doi.org/10.3390/md17020089 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Anjum, Komal
Kaleem, Sidra
Yi, Wenwen
Zheng, Guowan
Lian, Xiaoyuan
Zhang, Zhizhen
Novel Antimicrobial Indolepyrazines A and B from the Marine-Associated Acinetobacter sp. ZZ1275
title Novel Antimicrobial Indolepyrazines A and B from the Marine-Associated Acinetobacter sp. ZZ1275
title_full Novel Antimicrobial Indolepyrazines A and B from the Marine-Associated Acinetobacter sp. ZZ1275
title_fullStr Novel Antimicrobial Indolepyrazines A and B from the Marine-Associated Acinetobacter sp. ZZ1275
title_full_unstemmed Novel Antimicrobial Indolepyrazines A and B from the Marine-Associated Acinetobacter sp. ZZ1275
title_short Novel Antimicrobial Indolepyrazines A and B from the Marine-Associated Acinetobacter sp. ZZ1275
title_sort novel antimicrobial indolepyrazines a and b from the marine-associated acinetobacter sp. zz1275
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410138/
https://www.ncbi.nlm.nih.gov/pubmed/30717135
http://dx.doi.org/10.3390/md17020089
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