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Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C(10))

Salcaprozate sodium (SNAC) and sodium caprate (C(10)) are two of the most advanced intestinal permeation enhancers (PEs) that have been tested in clinical trials for oral delivery of macromolecules. Their effects on intestinal epithelia were studied for over 30 years, yet there is still debate over...

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Detalles Bibliográficos
Autores principales: Twarog, Caroline, Fattah, Sarinj, Heade, Joanne, Maher, Sam, Fattal, Elias, Brayden, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410172/
https://www.ncbi.nlm.nih.gov/pubmed/30781867
http://dx.doi.org/10.3390/pharmaceutics11020078