Dual Action of the PN159/KLAL/MAP Peptide: Increase of Drug Penetration across Caco-2 Intestinal Barrier Model by Modulation of Tight Junctions and Plasma Membrane Permeability

The absorption of drugs is limited by the epithelial barriers of the gastrointestinal tract. One of the strategies to improve drug delivery is the modulation of barrier function by the targeted opening of epithelial tight junctions. In our previous study the 18-mer amphiphilic PN159 peptide was foun...

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Detalles Bibliográficos
Autores principales: Bocsik, Alexandra, Gróf, Ilona, Kiss, Lóránd, Ötvös, Ferenc, Zsíros, Ottó, Daruka, Lejla, Fülöp, Lívia, Vastag, Monika, Kittel, Ágnes, Imre, Norbert, Martinek, Tamás A., Pál, Csaba, Szabó-Révész, Piroska, Deli, Mária A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410202/
https://www.ncbi.nlm.nih.gov/pubmed/30744154
http://dx.doi.org/10.3390/pharmaceutics11020073

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