Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries

Virology has played an essential role in deciphering many immunological phenomena, thus shaping our current understanding of the immune system. Animal models of viral infection and human viral infections were both important tools for immunological discoveries. This review discusses two immunological...

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Autor principal: Abdel-Hakeem, Mohamed S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410308/
https://www.ncbi.nlm.nih.gov/pubmed/30691215
http://dx.doi.org/10.3390/v11020106
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author Abdel-Hakeem, Mohamed S.
author_facet Abdel-Hakeem, Mohamed S.
author_sort Abdel-Hakeem, Mohamed S.
collection PubMed
description Virology has played an essential role in deciphering many immunological phenomena, thus shaping our current understanding of the immune system. Animal models of viral infection and human viral infections were both important tools for immunological discoveries. This review discusses two immunological breakthroughs originally identified with the help of the lymphocytic choriomeningitis virus (LCMV) model; immunological restriction by major histocompatibility complex and immunotherapy using checkpoint blockade. In addition, we discuss related discoveries such as development of tetramers, viral escape mutation, and the phenomenon of T-cell exhaustion.
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spelling pubmed-64103082019-04-01 Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries Abdel-Hakeem, Mohamed S. Viruses Review Virology has played an essential role in deciphering many immunological phenomena, thus shaping our current understanding of the immune system. Animal models of viral infection and human viral infections were both important tools for immunological discoveries. This review discusses two immunological breakthroughs originally identified with the help of the lymphocytic choriomeningitis virus (LCMV) model; immunological restriction by major histocompatibility complex and immunotherapy using checkpoint blockade. In addition, we discuss related discoveries such as development of tetramers, viral escape mutation, and the phenomenon of T-cell exhaustion. MDPI 2019-01-27 /pmc/articles/PMC6410308/ /pubmed/30691215 http://dx.doi.org/10.3390/v11020106 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Abdel-Hakeem, Mohamed S.
Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries
title Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries
title_full Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries
title_fullStr Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries
title_full_unstemmed Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries
title_short Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries
title_sort viruses teaching immunology: role of lcmv model and human viral infections in immunological discoveries
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410308/
https://www.ncbi.nlm.nih.gov/pubmed/30691215
http://dx.doi.org/10.3390/v11020106
work_keys_str_mv AT abdelhakeemmohameds virusesteachingimmunologyroleoflcmvmodelandhumanviralinfectionsinimmunologicaldiscoveries

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