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Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids

Recent advances in generating three-dimensional (3D) organoid systems from stem cells offer new possibilities for disease modeling and drug screening because organoids can recapitulate aspects of in vivo architecture and physiology. In this study, we generate isogenic 3D midbrain organoids with or w...

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Detalles Bibliográficos
Autores principales:	Kim, Hongwon, Park, Hyeok Ju, Choi, Hwan, Chang, Yujung, Park, Hanseul, Shin, Jaein, Kim, Junyeop, Lengner, Christopher J., Lee, Yong Kyu, Kim, Jongpil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410341/ https://www.ncbi.nlm.nih.gov/pubmed/30799274 http://dx.doi.org/10.1016/j.stemcr.2019.01.020

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