Epsins Regulate Mouse Embryonic Stem Cell Exit from Pluripotency and Neural Commitment by Controlling Notch Activation

Epsins are part of the internalization machinery pivotal to control clathrin-mediated endocytosis. Here, we report that epsin family members are expressed in mouse embryonic stem cells (mESCs) and that epsin1/2 knockdown alters both mESC exits from pluripotency and their differentiation. Furthermore...

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Detalles Bibliográficos
Autores principales: Cardano, Marina, Zasso, Jacopo, Ruggiero, Luca, Di Giacomo, Giuseppina, Marcatili, Matteo, Cremona, Ottavio, Conti, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410434/
https://www.ncbi.nlm.nih.gov/pubmed/30930949
http://dx.doi.org/10.1155/2019/4084351

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