SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology

VPS10P domain receptors emerge as central regulators of intracellular protein sorting in neurons with relevance for various brain pathologies. Here, we identified a role for the family member SorCS2 in protection of neurons from oxidative stress and epilepsy-induced cell death. We show that SorCS2 a...

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Detalles Bibliográficos
Autores principales: Malik, Anna R., Szydlowska, Kinga, Nizinska, Karolina, Asaro, Antonino, van Vliet, Erwin A., Popp, Oliver, Dittmar, Gunnar, Fritsche-Guenther, Raphaela, Kirwan, Jennifer A., Nykjaer, Anders, Lukasiuk, Katarzyna, Aronica, Eleonora, Willnow, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410498/
https://www.ncbi.nlm.nih.gov/pubmed/30840898
http://dx.doi.org/10.1016/j.celrep.2019.02.027

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