p53-targeted lincRNA-p21 acts as a tumor suppressor by inhibiting JAK2/STAT3 signaling pathways in head and neck squamous cell carcinoma

BACKGROUND: Long intergenic noncoding RNA p21 (lincRNA-p21) is considered a target of wild-type p53, but little is known about its regulation by mutant p53 and its functions during the progression of head and neck squamous cell carcinoma (HNSCC). METHODS: RNAscope was used to detect the expression a...

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Detalles Bibliográficos
Autores principales: Jin, Shufang, Yang, Xi, Li, Jiayi, Yang, Wenyi, Ma, Hailong, Zhang, Zhiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410525/
https://www.ncbi.nlm.nih.gov/pubmed/30857539
http://dx.doi.org/10.1186/s12943-019-0993-3

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