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Heart failure in Southeast Asia: facts and numbers

Southeast Asia is home to a growing population of >600 million people, the majority younger than 65 years, but among whom, rapid epidemiological transition has led to high rates of premature death from non‐communicable diseases (chiefly cardiovascular disease) (up to 28% in the Philippines vs. 12...

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Autor principal: Lam, Carolyn S.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410537/
https://www.ncbi.nlm.nih.gov/pubmed/28834655
http://dx.doi.org/10.1002/ehf2.12036
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author Lam, Carolyn S.P.
author_facet Lam, Carolyn S.P.
author_sort Lam, Carolyn S.P.
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description Southeast Asia is home to a growing population of >600 million people, the majority younger than 65 years, but among whom, rapid epidemiological transition has led to high rates of premature death from non‐communicable diseases (chiefly cardiovascular disease) (up to 28% in the Philippines vs. 12% in UK). There is a strikingly high prevalence of stage A heart failure (HF) risk factors in Southeast Asia, particularly hypertension (>24% in Cambodia and Laos vs. 13–15% in UK and USA), tobacco smoking (>36% in Indonesia), physical inactivity (>50% in Malaysia) and raised blood glucose (10–11% in Brunei, Malaysia, Singapore and Thailand) in spite of a low prevalence of overweight/obesity (21–26% in Southeast Asia vs. 67–70% in UK and USA). Accordingly, the prevalence of symptomatic HF appears to be higher in Southeast Asian countries compared with the rest of the world. Epidemiologic trends in Singapore showed a sharp 38% increase in age‐adjusted HF hospitalizations (from 85.4 per 10 000 in 1991 to 110.3 per 10 000 in 1998) with notable ethnic differences (hospitalization rates ~35% higher in Malays and Indians vs. Chinese; mortality 3.5 times higher in Malays vs. Indians and Chinese). Furthermore, Southeast Asian patients present with acute HF at a younger age (54 years) compared with USA patients (75 years) but have more severe clinical features, higher rates of mechanical ventilation, longer lengths of stay (6 vs. 4.2 days) and higher in‐hospital mortality (4.8 vs. 3.0%). Finally, there is under‐usage of guideline‐recommended HF medical therapies (prescribed in 31–63% of patients upon discharge) and device therapies in Southeast Asia. Large gaps in knowledge that need to be addressed in Southeast Asia include the prevalence of HF with preserved ejection fraction, clinical outcomes, barriers to recommended therapies and their cost‐effectiveness, as well as possible ethnicity‐specific pathophysiologic mechanisms.
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spelling pubmed-64105372019-03-22 Heart failure in Southeast Asia: facts and numbers Lam, Carolyn S.P. ESC Heart Fail Editorials Southeast Asia is home to a growing population of >600 million people, the majority younger than 65 years, but among whom, rapid epidemiological transition has led to high rates of premature death from non‐communicable diseases (chiefly cardiovascular disease) (up to 28% in the Philippines vs. 12% in UK). There is a strikingly high prevalence of stage A heart failure (HF) risk factors in Southeast Asia, particularly hypertension (>24% in Cambodia and Laos vs. 13–15% in UK and USA), tobacco smoking (>36% in Indonesia), physical inactivity (>50% in Malaysia) and raised blood glucose (10–11% in Brunei, Malaysia, Singapore and Thailand) in spite of a low prevalence of overweight/obesity (21–26% in Southeast Asia vs. 67–70% in UK and USA). Accordingly, the prevalence of symptomatic HF appears to be higher in Southeast Asian countries compared with the rest of the world. Epidemiologic trends in Singapore showed a sharp 38% increase in age‐adjusted HF hospitalizations (from 85.4 per 10 000 in 1991 to 110.3 per 10 000 in 1998) with notable ethnic differences (hospitalization rates ~35% higher in Malays and Indians vs. Chinese; mortality 3.5 times higher in Malays vs. Indians and Chinese). Furthermore, Southeast Asian patients present with acute HF at a younger age (54 years) compared with USA patients (75 years) but have more severe clinical features, higher rates of mechanical ventilation, longer lengths of stay (6 vs. 4.2 days) and higher in‐hospital mortality (4.8 vs. 3.0%). Finally, there is under‐usage of guideline‐recommended HF medical therapies (prescribed in 31–63% of patients upon discharge) and device therapies in Southeast Asia. Large gaps in knowledge that need to be addressed in Southeast Asia include the prevalence of HF with preserved ejection fraction, clinical outcomes, barriers to recommended therapies and their cost‐effectiveness, as well as possible ethnicity‐specific pathophysiologic mechanisms. John Wiley and Sons Inc. 2015-05-06 /pmc/articles/PMC6410537/ /pubmed/28834655 http://dx.doi.org/10.1002/ehf2.12036 Text en © 2015 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Editorials
Lam, Carolyn S.P.
Heart failure in Southeast Asia: facts and numbers
title Heart failure in Southeast Asia: facts and numbers
title_full Heart failure in Southeast Asia: facts and numbers
title_fullStr Heart failure in Southeast Asia: facts and numbers
title_full_unstemmed Heart failure in Southeast Asia: facts and numbers
title_short Heart failure in Southeast Asia: facts and numbers
title_sort heart failure in southeast asia: facts and numbers
topic Editorials
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410537/
https://www.ncbi.nlm.nih.gov/pubmed/28834655
http://dx.doi.org/10.1002/ehf2.12036
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