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Primary salivary gland-type tumors of the lung: A systematic review and pooled analysis
INTRODUCTION: Primary salivary gland-type tumors of the lung (PSGTTL) are rare intrathoracic malignant neoplasms. Their description in literature is largely limited to a few case series and case reports. A systematic review and pooled analysis of the previously reported cases of PSGTTL is presented...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410586/ https://www.ncbi.nlm.nih.gov/pubmed/30829245 http://dx.doi.org/10.4103/lungindia.lungindia_284_18 |
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author | Garg, Pankaj Kumar Sharma, Gopal Rai, Shreyash Jakhetiya, Ashish |
author_facet | Garg, Pankaj Kumar Sharma, Gopal Rai, Shreyash Jakhetiya, Ashish |
author_sort | Garg, Pankaj Kumar |
collection | PubMed |
description | INTRODUCTION: Primary salivary gland-type tumors of the lung (PSGTTL) are rare intrathoracic malignant neoplasms. Their description in literature is largely limited to a few case series and case reports. A systematic review and pooled analysis of the previously reported cases of PSGTTL is presented here. METHODS: Electronic database of PubMed using keywords “lung neoplasm” AND “salivary gland tumors” was used to identify the papers documenting the PSGTTL. Filters (publication date from January 1, 1900–-December 31, 2015, Humans and English) were applied to refine the search. A pooled analysis of clinical, pathological, treatment, and survival data was performed. RESULTS: The present systematic review included 5 studies and a total of 233 patients. Mean age of the patients was 41 years (range 6–80 years) and there was a male preponderance (1.3:1). Common pathological types were mucoepidermoid (MEC) (56.6%), adenoid cystic (ACC) (39.5%), and epithelial-myoepithelial cancer (3.8%). Tumors were located in the central airways (trachea and major bronchi) in 43.3% of patients. Weighted median tumor size was 4.2 cm. Surgery was the primary treatment undertaken in 82.4% of the patients, while radiotherapy and chemotherapy were also used in 15.9% and 9.4% of the patients. Lymph node involvement was seen in 15.2% of the patients. Disease recurrences were observed in 21.1% of the patients (12.9% and 37.5% in MEC and ACC, respectively). Three-, 5-, and 10-year weighted overall survival was 86.4%, 81.4%, and 73.6% (93.8%, 90.0%, and 85.0%, respectively, for MEC and 76.7%, 62.8%, and 50.5%, respectively, for ACC). CONCLUSION: Surgery is the primary treatment of PSGTTL to achieve long-term survival. Role of chemotherapy and radiotherapy in the management of PSGTTL warrants further studies. |
format | Online Article Text |
id | pubmed-6410586 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-64105862019-04-17 Primary salivary gland-type tumors of the lung: A systematic review and pooled analysis Garg, Pankaj Kumar Sharma, Gopal Rai, Shreyash Jakhetiya, Ashish Lung India Original Article INTRODUCTION: Primary salivary gland-type tumors of the lung (PSGTTL) are rare intrathoracic malignant neoplasms. Their description in literature is largely limited to a few case series and case reports. A systematic review and pooled analysis of the previously reported cases of PSGTTL is presented here. METHODS: Electronic database of PubMed using keywords “lung neoplasm” AND “salivary gland tumors” was used to identify the papers documenting the PSGTTL. Filters (publication date from January 1, 1900–-December 31, 2015, Humans and English) were applied to refine the search. A pooled analysis of clinical, pathological, treatment, and survival data was performed. RESULTS: The present systematic review included 5 studies and a total of 233 patients. Mean age of the patients was 41 years (range 6–80 years) and there was a male preponderance (1.3:1). Common pathological types were mucoepidermoid (MEC) (56.6%), adenoid cystic (ACC) (39.5%), and epithelial-myoepithelial cancer (3.8%). Tumors were located in the central airways (trachea and major bronchi) in 43.3% of patients. Weighted median tumor size was 4.2 cm. Surgery was the primary treatment undertaken in 82.4% of the patients, while radiotherapy and chemotherapy were also used in 15.9% and 9.4% of the patients. Lymph node involvement was seen in 15.2% of the patients. Disease recurrences were observed in 21.1% of the patients (12.9% and 37.5% in MEC and ACC, respectively). Three-, 5-, and 10-year weighted overall survival was 86.4%, 81.4%, and 73.6% (93.8%, 90.0%, and 85.0%, respectively, for MEC and 76.7%, 62.8%, and 50.5%, respectively, for ACC). CONCLUSION: Surgery is the primary treatment of PSGTTL to achieve long-term survival. Role of chemotherapy and radiotherapy in the management of PSGTTL warrants further studies. Medknow Publications & Media Pvt Ltd 2019 /pmc/articles/PMC6410586/ /pubmed/30829245 http://dx.doi.org/10.4103/lungindia.lungindia_284_18 Text en Copyright: © 2019 Indian Chest Society http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Garg, Pankaj Kumar Sharma, Gopal Rai, Shreyash Jakhetiya, Ashish Primary salivary gland-type tumors of the lung: A systematic review and pooled analysis |
title | Primary salivary gland-type tumors of the lung: A systematic review and pooled analysis |
title_full | Primary salivary gland-type tumors of the lung: A systematic review and pooled analysis |
title_fullStr | Primary salivary gland-type tumors of the lung: A systematic review and pooled analysis |
title_full_unstemmed | Primary salivary gland-type tumors of the lung: A systematic review and pooled analysis |
title_short | Primary salivary gland-type tumors of the lung: A systematic review and pooled analysis |
title_sort | primary salivary gland-type tumors of the lung: a systematic review and pooled analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410586/ https://www.ncbi.nlm.nih.gov/pubmed/30829245 http://dx.doi.org/10.4103/lungindia.lungindia_284_18 |
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