Mechanistic Investigation of the Androgen Receptor DNA-Binding Domain Inhibitor Pyrvinium

[Image: see text] Pyrvinium was identified as the first small molecule inhibitor of the androgen receptor (AR) DNA-binding domain (DBD). It was also among the first small molecules shown to directly inhibit the activity of AR splice variants (ARVs), which has important clinical implications in the t...

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Detalles Bibliográficos
Autores principales: Pal, Sumanta K., Tew, Ben Yi, Lim, Minyoung, Stankavich, Brittany, He, Miaoling, Pufall, Miles, Hu, Weidong, Chen, Yuan, Jones, Jeremy O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410682/
https://www.ncbi.nlm.nih.gov/pubmed/30873507
http://dx.doi.org/10.1021/acsomega.8b03205

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