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Increased risk of obstructive sleep apnoea in women with polycystic ovary syndrome: a population-based cohort study

OBJECTIVE: Obesity is very common in patients with obstructive sleep apnoea (OSA) and polycystic ovary syndrome (PCOS). Longitudinal studies assessing OSA risk in PCOS and examining the role of obesity are lacking. Our objective was to assess the risk of OSA in women with vs without PCOS and to exam...

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Autores principales: Kumarendran, Balachandran, Sumilo, Dana, O’Reilly, Michael W, Toulis, Konstantinos A, Gokhale, Krishna M, Wijeyaratne, Chandrika N, Coomarasamy, Arri, Arlt, Wiebke, Tahrani, Abd A, Nirantharakumar, Krishnarajah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410684/
https://www.ncbi.nlm.nih.gov/pubmed/30763274
http://dx.doi.org/10.1530/EJE-18-0693
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author Kumarendran, Balachandran
Sumilo, Dana
O’Reilly, Michael W
Toulis, Konstantinos A
Gokhale, Krishna M
Wijeyaratne, Chandrika N
Coomarasamy, Arri
Arlt, Wiebke
Tahrani, Abd A
Nirantharakumar, Krishnarajah
author_facet Kumarendran, Balachandran
Sumilo, Dana
O’Reilly, Michael W
Toulis, Konstantinos A
Gokhale, Krishna M
Wijeyaratne, Chandrika N
Coomarasamy, Arri
Arlt, Wiebke
Tahrani, Abd A
Nirantharakumar, Krishnarajah
author_sort Kumarendran, Balachandran
collection PubMed
description OBJECTIVE: Obesity is very common in patients with obstructive sleep apnoea (OSA) and polycystic ovary syndrome (PCOS). Longitudinal studies assessing OSA risk in PCOS and examining the role of obesity are lacking. Our objective was to assess the risk of OSA in women with vs without PCOS and to examine the role of obesity in the observed findings. DESIGN: Population-based retrospective cohort study utilizing The Health Improvement Network (THIN), UK. METHODS: 76 978 women with PCOS and 143 077 age-, BMI- and location-matched women without PCOS between January 2000 and May 2017 were identified. Hazard ratio (HR) for OSA among women with and without PCOS were calculated after controlling for confounding variables using multivariate Cox models. RESULTS: Median patient age was 30 (IQR: 25–35) years; median follow-up was 3.5 (IQR: 1.4–7.1) years. We found 298 OSA cases in PCOS women vs 222 in controls, with incidence rates for OSA of 8.1 and 3.3 per 10 000 person years, respectively. Women with PCOS were at increased risk of developing OSA (adjusted HR = 2.26, 95% CI: 1.89–2.69, P < 0.001), with similar HRs for normal weight, overweight and obese PCOS women. CONCLUSIONS: Women with PCOS are at increased risk of developing OSA compared to control women irrespective of obesity. Considering the significant metabolic morbidity associated with OSA, clinicians should have a low threshold to test for OSA in women with PCOS. Whether OSA treatment has an impact on PCOS symptoms and outcomes needs to be examined.
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spelling pubmed-64106842019-03-14 Increased risk of obstructive sleep apnoea in women with polycystic ovary syndrome: a population-based cohort study Kumarendran, Balachandran Sumilo, Dana O’Reilly, Michael W Toulis, Konstantinos A Gokhale, Krishna M Wijeyaratne, Chandrika N Coomarasamy, Arri Arlt, Wiebke Tahrani, Abd A Nirantharakumar, Krishnarajah Eur J Endocrinol Clinical Study OBJECTIVE: Obesity is very common in patients with obstructive sleep apnoea (OSA) and polycystic ovary syndrome (PCOS). Longitudinal studies assessing OSA risk in PCOS and examining the role of obesity are lacking. Our objective was to assess the risk of OSA in women with vs without PCOS and to examine the role of obesity in the observed findings. DESIGN: Population-based retrospective cohort study utilizing The Health Improvement Network (THIN), UK. METHODS: 76 978 women with PCOS and 143 077 age-, BMI- and location-matched women without PCOS between January 2000 and May 2017 were identified. Hazard ratio (HR) for OSA among women with and without PCOS were calculated after controlling for confounding variables using multivariate Cox models. RESULTS: Median patient age was 30 (IQR: 25–35) years; median follow-up was 3.5 (IQR: 1.4–7.1) years. We found 298 OSA cases in PCOS women vs 222 in controls, with incidence rates for OSA of 8.1 and 3.3 per 10 000 person years, respectively. Women with PCOS were at increased risk of developing OSA (adjusted HR = 2.26, 95% CI: 1.89–2.69, P < 0.001), with similar HRs for normal weight, overweight and obese PCOS women. CONCLUSIONS: Women with PCOS are at increased risk of developing OSA compared to control women irrespective of obesity. Considering the significant metabolic morbidity associated with OSA, clinicians should have a low threshold to test for OSA in women with PCOS. Whether OSA treatment has an impact on PCOS symptoms and outcomes needs to be examined. Bioscientifica Ltd 2019-02-13 /pmc/articles/PMC6410684/ /pubmed/30763274 http://dx.doi.org/10.1530/EJE-18-0693 Text en © 2019 The authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Clinical Study
Kumarendran, Balachandran
Sumilo, Dana
O’Reilly, Michael W
Toulis, Konstantinos A
Gokhale, Krishna M
Wijeyaratne, Chandrika N
Coomarasamy, Arri
Arlt, Wiebke
Tahrani, Abd A
Nirantharakumar, Krishnarajah
Increased risk of obstructive sleep apnoea in women with polycystic ovary syndrome: a population-based cohort study
title Increased risk of obstructive sleep apnoea in women with polycystic ovary syndrome: a population-based cohort study
title_full Increased risk of obstructive sleep apnoea in women with polycystic ovary syndrome: a population-based cohort study
title_fullStr Increased risk of obstructive sleep apnoea in women with polycystic ovary syndrome: a population-based cohort study
title_full_unstemmed Increased risk of obstructive sleep apnoea in women with polycystic ovary syndrome: a population-based cohort study
title_short Increased risk of obstructive sleep apnoea in women with polycystic ovary syndrome: a population-based cohort study
title_sort increased risk of obstructive sleep apnoea in women with polycystic ovary syndrome: a population-based cohort study
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410684/
https://www.ncbi.nlm.nih.gov/pubmed/30763274
http://dx.doi.org/10.1530/EJE-18-0693
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