PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin

Precise modulation of hepatic glucose metabolism is crucial during the fasting and feeding cycle and is controlled by the actions of circulating insulin and glucagon. The insulin-signaling pathway requires insulin receptor substrate 1 (IRS1) and IRS2, which are found to be dysregulated in diabetes a...

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Detalles Bibliográficos
Autores principales: Besse-Patin, Aurèle, Jeromson, Stewart, Levesque-Damphousse, Philipa, Secco, Blandine, Laplante, Mathieu, Estall, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410797/
https://www.ncbi.nlm.nih.gov/pubmed/30770439
http://dx.doi.org/10.1073/pnas.1815150116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410797/
https://www.ncbi.nlm.nih.gov/pubmed/30770439
http://dx.doi.org/10.1073/pnas.1815150116

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