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Differential cortical microstructural maturation in the preterm human brain with diffusion kurtosis and tensor imaging
During the third trimester, the human brain undergoes rapid cellular and molecular processes that reshape the structural architecture of the cerebral cortex. Knowledge of cortical differentiation obtained predominantly from histological studies is limited in localized and small cortical regions. How...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410816/ https://www.ncbi.nlm.nih.gov/pubmed/30782802 http://dx.doi.org/10.1073/pnas.1812156116 |
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author | Ouyang, Minhui Jeon, Tina Sotiras, Aristeidis Peng, Qinmu Mishra, Virendra Halovanic, Cathy Chen, Min Chalak, Lina Rollins, Nancy Roberts, Timothy P. L. Davatzikos, Christos Huang, Hao |
author_facet | Ouyang, Minhui Jeon, Tina Sotiras, Aristeidis Peng, Qinmu Mishra, Virendra Halovanic, Cathy Chen, Min Chalak, Lina Rollins, Nancy Roberts, Timothy P. L. Davatzikos, Christos Huang, Hao |
author_sort | Ouyang, Minhui |
collection | PubMed |
description | During the third trimester, the human brain undergoes rapid cellular and molecular processes that reshape the structural architecture of the cerebral cortex. Knowledge of cortical differentiation obtained predominantly from histological studies is limited in localized and small cortical regions. How cortical microstructure is differentiated across cortical regions in this critical period is unknown. In this study, the cortical microstructural architecture across the entire cortex was delineated with non-Gaussian diffusion kurtosis imaging as well as conventional diffusion tensor imaging of 89 preterm neonates aged 31–42 postmenstrual weeks. The temporal changes of cortical mean kurtosis (MK) or fractional anisotropy (FA) were heterogeneous across the cortical regions. Cortical MK decreases were observed throughout the studied age period, while cortical FA decrease reached its plateau around 37 weeks. More rapid decreases in MK were found in the primary visual region, while faster FA declines were observed in the prefrontal cortex. We found that distinctive cortical microstructural changes were coupled with microstructural maturation of associated white matter tracts. Both cortical MK and FA measurements predicted the postmenstrual age of preterm infants accurately. This study revealed a differential 4D spatiotemporal cytoarchitectural signature inferred by non-Gaussian diffusion barriers inside the cortical plate during the third trimester. The cytoarchitectural processes, including dendritic arborization and neuronal density decreases, were inferred by regional cortical FA and MK measurements. The presented findings suggest that cortical MK and FA measurements could be used as effective imaging markers for cortical microstructural changes in typical and potentially atypical brain development. |
format | Online Article Text |
id | pubmed-6410816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-64108162019-03-13 Differential cortical microstructural maturation in the preterm human brain with diffusion kurtosis and tensor imaging Ouyang, Minhui Jeon, Tina Sotiras, Aristeidis Peng, Qinmu Mishra, Virendra Halovanic, Cathy Chen, Min Chalak, Lina Rollins, Nancy Roberts, Timothy P. L. Davatzikos, Christos Huang, Hao Proc Natl Acad Sci U S A PNAS Plus During the third trimester, the human brain undergoes rapid cellular and molecular processes that reshape the structural architecture of the cerebral cortex. Knowledge of cortical differentiation obtained predominantly from histological studies is limited in localized and small cortical regions. How cortical microstructure is differentiated across cortical regions in this critical period is unknown. In this study, the cortical microstructural architecture across the entire cortex was delineated with non-Gaussian diffusion kurtosis imaging as well as conventional diffusion tensor imaging of 89 preterm neonates aged 31–42 postmenstrual weeks. The temporal changes of cortical mean kurtosis (MK) or fractional anisotropy (FA) were heterogeneous across the cortical regions. Cortical MK decreases were observed throughout the studied age period, while cortical FA decrease reached its plateau around 37 weeks. More rapid decreases in MK were found in the primary visual region, while faster FA declines were observed in the prefrontal cortex. We found that distinctive cortical microstructural changes were coupled with microstructural maturation of associated white matter tracts. Both cortical MK and FA measurements predicted the postmenstrual age of preterm infants accurately. This study revealed a differential 4D spatiotemporal cytoarchitectural signature inferred by non-Gaussian diffusion barriers inside the cortical plate during the third trimester. The cytoarchitectural processes, including dendritic arborization and neuronal density decreases, were inferred by regional cortical FA and MK measurements. The presented findings suggest that cortical MK and FA measurements could be used as effective imaging markers for cortical microstructural changes in typical and potentially atypical brain development. National Academy of Sciences 2019-03-05 2019-02-19 /pmc/articles/PMC6410816/ /pubmed/30782802 http://dx.doi.org/10.1073/pnas.1812156116 Text en Copyright © 2019 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | PNAS Plus Ouyang, Minhui Jeon, Tina Sotiras, Aristeidis Peng, Qinmu Mishra, Virendra Halovanic, Cathy Chen, Min Chalak, Lina Rollins, Nancy Roberts, Timothy P. L. Davatzikos, Christos Huang, Hao Differential cortical microstructural maturation in the preterm human brain with diffusion kurtosis and tensor imaging |
title | Differential cortical microstructural maturation in the preterm human brain with diffusion kurtosis and tensor imaging |
title_full | Differential cortical microstructural maturation in the preterm human brain with diffusion kurtosis and tensor imaging |
title_fullStr | Differential cortical microstructural maturation in the preterm human brain with diffusion kurtosis and tensor imaging |
title_full_unstemmed | Differential cortical microstructural maturation in the preterm human brain with diffusion kurtosis and tensor imaging |
title_short | Differential cortical microstructural maturation in the preterm human brain with diffusion kurtosis and tensor imaging |
title_sort | differential cortical microstructural maturation in the preterm human brain with diffusion kurtosis and tensor imaging |
topic | PNAS Plus |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410816/ https://www.ncbi.nlm.nih.gov/pubmed/30782802 http://dx.doi.org/10.1073/pnas.1812156116 |
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