Cargando…

Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia

Ubiquitin C-terminal hydrolase L1 (UCHL1) is a unique brain-specific deubiquitinating enzyme. Mutations in and aberrant function of UCHL1 have been linked to many neurological disorders. UCHL1 activity protects neurons from hypoxic injury, and binding of stroke-induced reactive lipid species to the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Hao, Povysheva, Nadya, Rose, Marie E., Mi, Zhiping, Banton, Joseph S., Li, Wenjin, Chen, Fenghua, Reay, Daniel P., Barrionuevo, Germán, Zhang, Feng, Graham, Steven H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410860/ https://www.ncbi.nlm.nih.gov/pubmed/30760601 http://dx.doi.org/10.1073/pnas.1821282116

Ejemplares similares

Phosphatidylserine save-me signals drive functional recovery of severed axons in Caenorhabditis elegans
por: Abay, Zehra C., et al.
Publicado: (2017)

Regulation of axon repulsion by MAX-1 SUMOylation and AP-3
por: Chen, Shih-Yu, et al.
Publicado: (2018)

Involvement of advillin in somatosensory neuron subtype-specific axon regeneration and neuropathic pain
por: Chuang, Yu-Chia, et al.
Publicado: (2018)

ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity
por: Yang, Rui, et al.
Publicado: (2019)

hnRNP R and its main interactor, the noncoding RNA 7SK, coregulate the axonal transcriptome of motoneurons
por: Briese, Michael, et al.
Publicado: (2018)

Single-molecule analysis of endogenous β-actin mRNA trafficking reveals a mechanism for compartmentalized mRNA localization in axons
por: Turner-Bridger, Benita, et al.
Publicado: (2018)

let-7 miRNA controls CED-7 homotypic adhesion and EFF-1–mediated axonal self-fusion to restore touch sensation following injury
por: Basu, Atrayee, et al.
Publicado: (2017)

Organizing principles for the cerebral cortex network of commissural and association connections
por: Swanson, Larry W., et al.
Publicado: (2017)

Gradual progression from sensory to task-related processing in cerebral cortex
por: Brincat, Scott L., et al.
Publicado: (2018)

A stress recovery signaling network for enhanced flooding tolerance in Arabidopsis thaliana
por: Yeung, Elaine, et al.
Publicado: (2018)

Region-specific and activity-dependent regulation of SVZ neurogenesis and recovery after stroke
por: Liang, Huixuan, et al.
Publicado: (2019)

Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia
por: Kanaji, Taisuke, et al.
Publicado: (2018)

In vivo imaging reveals transient microglia recruitment and functional recovery of photoreceptor signaling after injury
por: Miller, Eric B., et al.
Publicado: (2019)

Nanoscale remodeling of ryanodine receptor cluster size underlies cerebral microvascular dysfunction in Duchenne muscular dystrophy
por: Pritchard, Harry A. T., et al.
Publicado: (2018)

Linkage between retinal ganglion cell density and the nonuniform spatial integration across the visual field
por: Kwon, MiYoung, et al.
Publicado: (2019)

Whole-genome data reveal the complex history of a diverse ecological community
por: Bunnefeld, Lynsey, et al.
Publicado: (2018)

Energy-dependent quenching adjusts the excitation diffusion length to regulate photosynthetic light harvesting
por: Bennett, Doran I. G., et al.
Publicado: (2018)

Stabilized single-injection inactivated polio vaccine elicits a strong neutralizing immune response
por: Tzeng, Stephany Y., et al.
Publicado: (2018)

Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia
por: Yung, Hong Wa, et al.
Publicado: (2019)

Distinction of self-produced touch and social touch at cortical and spinal cord levels
por: Boehme, Rebecca, et al.
Publicado: (2019)

Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis
por: Chen, QiXing, et al.
Publicado: (2019)

Structural characterization of the D290V mutation site in hnRNPA2 low-complexity–domain polymers
por: Murray, Dylan T., et al.
Publicado: (2018)

Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors
por: Chernov-Rogan, Tania, et al.
Publicado: (2018)

Repertoire-wide phylogenetic models of B cell molecular evolution reveal evolutionary signatures of aging and vaccination
por: Hoehn, Kenneth B., et al.
Publicado: (2019)

Low-oxygen response is triggered by an ATP-dependent shift in oleoyl-CoA in Arabidopsis
por: Schmidt, Romy R., et al.
Publicado: (2018)

Retinal microglia initiate neuroinflammation in ocular autoimmunity
por: Okunuki, Yoko, et al.
Publicado: (2019)

Boron–oxygen complex yields n-type surface layer in semiconducting diamond
por: Liu, Xiaobing, et al.
Publicado: (2019)

Circular DNA tumor viruses make circular RNAs
por: Toptan, Tuna, et al.
Publicado: (2018)

Modeling cocaine traffickers and counterdrug interdiction forces as a complex adaptive system
por: Magliocca, Nicholas R., et al.
Publicado: (2019)

An inhibitor of complement C5 provides structural insights into activation
por: Reichhardt, Martin P., et al.
Publicado: (2020)

Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects
por: Kwon, Min Jee, et al.
Publicado: (2018)

FBXW7-mediated stability regulation of signal transducer and activator of transcription 2 in melanoma formation
por: Lee, Cheol-Jung, et al.
Publicado: (2020)

Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain
por: Gallego-Bartolomé, Javier, et al.
Publicado: (2018)

Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir
por: Das, Biswajit, et al.
Publicado: (2018)

Caulobacter crescentus Hfq structure reveals a conserved mechanism of RNA annealing regulation
por: Santiago-Frangos, Andrew, et al.
Publicado: (2019)

Gravity of human impacts mediates coral reef conservation gains
por: Cinner, Joshua E., et al.
Publicado: (2018)

Spontaneous driving forces give rise to protein−RNA condensates with coexisting phases and complex material properties
por: Boeynaems, Steven, et al.
Publicado: (2019)

Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction
por: Hillig, Roman C., et al.
Publicado: (2019)

A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability
por: Sadler, Jessica B. A., et al.
Publicado: (2018)

Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells
por: Gennaro, Victoria J., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_s7dsvbtf46e4v532j2mo104vpg