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A fresh look at angiogenesis in juvenile idiopathic arthritis
Angiogenesis is the complex process of creating new capillaries from preexisting blood vessels due to hypoxemia, injury or inflammation of the tissues. Numerous cytokines and cell mediators have been identified to induce and stimulate angiogenesis, but vascular endothelial growth factor (VEGF) is a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Polish Society of Experimental and Clinical Immunology
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410962/ https://www.ncbi.nlm.nih.gov/pubmed/30863199 http://dx.doi.org/10.5114/ceji.2018.80052 |
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author | Świdrowska-Jaros, Joanna Smolewska, Elżbieta |
author_facet | Świdrowska-Jaros, Joanna Smolewska, Elżbieta |
author_sort | Świdrowska-Jaros, Joanna |
collection | PubMed |
description | Angiogenesis is the complex process of creating new capillaries from preexisting blood vessels due to hypoxemia, injury or inflammation of the tissues. Numerous cytokines and cell mediators have been identified to induce and stimulate angiogenesis, but vascular endothelial growth factor (VEGF) is a key regulator. The role of proangiogenic factors in the pathogenesis of chronic arthritis is currently a subject of intensive investigations in adult patients with rheumatoid arthritis (RA) and, to a limited extent, in children with juvenile idiopathic arthritis (JIA). Recent studies has shown a significant correlation between proangiogenic marker concentrations and the severity of inflammation in either RA or JIA patients. The serum neovascularization markers correlate with the power Doppler ultrasound image of the inflamed joint and hypertrophic synovium, which may be connected with the disease activity. The aim of this paper is to describe the state of the art on the important role of angiogenesis in adult and childhood rheumatoid arthritis. |
format | Online Article Text |
id | pubmed-6410962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Polish Society of Experimental and Clinical Immunology |
record_format | MEDLINE/PubMed |
spelling | pubmed-64109622019-03-12 A fresh look at angiogenesis in juvenile idiopathic arthritis Świdrowska-Jaros, Joanna Smolewska, Elżbieta Cent Eur J Immunol Review Paper Angiogenesis is the complex process of creating new capillaries from preexisting blood vessels due to hypoxemia, injury or inflammation of the tissues. Numerous cytokines and cell mediators have been identified to induce and stimulate angiogenesis, but vascular endothelial growth factor (VEGF) is a key regulator. The role of proangiogenic factors in the pathogenesis of chronic arthritis is currently a subject of intensive investigations in adult patients with rheumatoid arthritis (RA) and, to a limited extent, in children with juvenile idiopathic arthritis (JIA). Recent studies has shown a significant correlation between proangiogenic marker concentrations and the severity of inflammation in either RA or JIA patients. The serum neovascularization markers correlate with the power Doppler ultrasound image of the inflamed joint and hypertrophic synovium, which may be connected with the disease activity. The aim of this paper is to describe the state of the art on the important role of angiogenesis in adult and childhood rheumatoid arthritis. Polish Society of Experimental and Clinical Immunology 2018-10-30 2018 /pmc/articles/PMC6410962/ /pubmed/30863199 http://dx.doi.org/10.5114/ceji.2018.80052 Text en Copyright: © 2018 Polish Society of Experimental and Clinical Immunology http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Review Paper Świdrowska-Jaros, Joanna Smolewska, Elżbieta A fresh look at angiogenesis in juvenile idiopathic arthritis |
title | A fresh look at angiogenesis in juvenile idiopathic arthritis |
title_full | A fresh look at angiogenesis in juvenile idiopathic arthritis |
title_fullStr | A fresh look at angiogenesis in juvenile idiopathic arthritis |
title_full_unstemmed | A fresh look at angiogenesis in juvenile idiopathic arthritis |
title_short | A fresh look at angiogenesis in juvenile idiopathic arthritis |
title_sort | fresh look at angiogenesis in juvenile idiopathic arthritis |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410962/ https://www.ncbi.nlm.nih.gov/pubmed/30863199 http://dx.doi.org/10.5114/ceji.2018.80052 |
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