Cargando…
‘Building a perfect body’: control of vertebrate organogenesis by PBX-dependent regulatory networks
Pbx genes encode transcription factors that belong to the TALE (three-amino-acid loop extension) superclass of homeodomain proteins. We have witnessed a surge in information about the roles of this gene family as leading actors in the transcriptional control of development. PBX proteins represent a...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411007/ https://www.ncbi.nlm.nih.gov/pubmed/30824532 http://dx.doi.org/10.1101/gad.318774.118 |
_version_ | 1783402330248445952 |
---|---|
author | Selleri, Licia Zappavigna, Vincenzo Ferretti, Elisabetta |
author_facet | Selleri, Licia Zappavigna, Vincenzo Ferretti, Elisabetta |
author_sort | Selleri, Licia |
collection | PubMed |
description | Pbx genes encode transcription factors that belong to the TALE (three-amino-acid loop extension) superclass of homeodomain proteins. We have witnessed a surge in information about the roles of this gene family as leading actors in the transcriptional control of development. PBX proteins represent a clear example of how transcription factors can regulate developmental processes by combinatorial properties, acting within multimeric complexes to implement activation or repression of transcription depending on their interaction partners. Here, we revisit long-emphasized functions of PBX transcription factors as cofactors for HOX proteins, major architects of the body plan. We further discuss new knowledge on roles of PBX proteins in different developmental contexts as upstream regulators of Hox genes—as factors that interact with non-HOX proteins and can work independently of HOX—as well as potential pioneer factors. Committed to building a perfect body, PBX proteins govern regulatory networks that direct essential morphogenetic processes and organogenesis in vertebrate development. Perturbations of PBX-dependent networks can cause human congenital disease and cancer. |
format | Online Article Text |
id | pubmed-6411007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-64110072019-09-01 ‘Building a perfect body’: control of vertebrate organogenesis by PBX-dependent regulatory networks Selleri, Licia Zappavigna, Vincenzo Ferretti, Elisabetta Genes Dev Review Pbx genes encode transcription factors that belong to the TALE (three-amino-acid loop extension) superclass of homeodomain proteins. We have witnessed a surge in information about the roles of this gene family as leading actors in the transcriptional control of development. PBX proteins represent a clear example of how transcription factors can regulate developmental processes by combinatorial properties, acting within multimeric complexes to implement activation or repression of transcription depending on their interaction partners. Here, we revisit long-emphasized functions of PBX transcription factors as cofactors for HOX proteins, major architects of the body plan. We further discuss new knowledge on roles of PBX proteins in different developmental contexts as upstream regulators of Hox genes—as factors that interact with non-HOX proteins and can work independently of HOX—as well as potential pioneer factors. Committed to building a perfect body, PBX proteins govern regulatory networks that direct essential morphogenetic processes and organogenesis in vertebrate development. Perturbations of PBX-dependent networks can cause human congenital disease and cancer. Cold Spring Harbor Laboratory Press 2019-03-01 /pmc/articles/PMC6411007/ /pubmed/30824532 http://dx.doi.org/10.1101/gad.318774.118 Text en © 2019 Selleri et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Review Selleri, Licia Zappavigna, Vincenzo Ferretti, Elisabetta ‘Building a perfect body’: control of vertebrate organogenesis by PBX-dependent regulatory networks |
title | ‘Building a perfect body’: control of vertebrate organogenesis by PBX-dependent regulatory networks |
title_full | ‘Building a perfect body’: control of vertebrate organogenesis by PBX-dependent regulatory networks |
title_fullStr | ‘Building a perfect body’: control of vertebrate organogenesis by PBX-dependent regulatory networks |
title_full_unstemmed | ‘Building a perfect body’: control of vertebrate organogenesis by PBX-dependent regulatory networks |
title_short | ‘Building a perfect body’: control of vertebrate organogenesis by PBX-dependent regulatory networks |
title_sort | ‘building a perfect body’: control of vertebrate organogenesis by pbx-dependent regulatory networks |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411007/ https://www.ncbi.nlm.nih.gov/pubmed/30824532 http://dx.doi.org/10.1101/gad.318774.118 |
work_keys_str_mv | AT sellerilicia buildingaperfectbodycontrolofvertebrateorganogenesisbypbxdependentregulatorynetworks AT zappavignavincenzo buildingaperfectbodycontrolofvertebrateorganogenesisbypbxdependentregulatorynetworks AT ferrettielisabetta buildingaperfectbodycontrolofvertebrateorganogenesisbypbxdependentregulatorynetworks |