BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma

Whether cell types exposed to a high level of environmental insults possess cell type-specific prosurvival mechanisms or enhanced DNA damage repair capacity is not well understood. BRN2 is a tissue-restricted POU domain transcription factor implicated in neural development and several cancers. In me...

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Detalles Bibliográficos
Autores principales: Herbert, Katharine, Binet, Romuald, Lambert, Jean-Philippe, Louphrasitthiphol, Pakavarin, Kalkavan, Halime, Sesma-Sanz, Laura, Robles-Espinoza, Carla Daniela, Sarkar, Sovan, Suer, Eda, Andrews, Sarah, Chauhan, Jagat, Roberts, Nicola D., Middleton, Mark R., Gingras, Anne-Claude, Masson, Jean-Yves, Larue, Lionel, Falletta, Paola, Goding, Colin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411009/
https://www.ncbi.nlm.nih.gov/pubmed/30804224
http://dx.doi.org/10.1101/gad.314633.118

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