A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-κB

The majority of supratentorial ependymomas (ST-ependymomas) have few mutations but frequently display chromothripsis of chromosome 11q that generates a fusion between C11orf95 and RELA (RELA(FUS)). Neural stem cells transduced with RELA(FUS) ex vivo form ependymomas when implanted in the brain. Thes...

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Detalles Bibliográficos
Autores principales: Ozawa, Tatsuya, Arora, Sonali, Szulzewsky, Frank, Juric-Sekhar, Gordana, Miyajima, Yoshiteru, Bolouri, Hamid, Yasui, Yoshie, Barber, Jason, Kupp, Robert, Dalton, James, Jones, Terreia S., Nakada, Mitsutoshi, Kumabe, Toshihiro, Ellison, David W., Gilbertson, Richard J., Holland, Eric C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411037/
https://www.ncbi.nlm.nih.gov/pubmed/29949764
http://dx.doi.org/10.1016/j.celrep.2018.04.099

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