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The related factors of sleep benefit in Parkinson’s disease: A systematic review and meta-analysis

BACKGROUND: Sleep benefit (SB) refers to the poorly understood phenomenon in Parkinson’s disease (PD) in which patients wake up in the morning with improved motor function. Although previous studies have suggested that several related factors are associated with SB, this relationship remains controv...

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Autores principales: Rui, Zhong, Qingling, Chen, Xinyue, Zhang, Xin, Zhang, Weihong, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411108/
https://www.ncbi.nlm.nih.gov/pubmed/30856190
http://dx.doi.org/10.1371/journal.pone.0212951
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author Rui, Zhong
Qingling, Chen
Xinyue, Zhang
Xin, Zhang
Weihong, Lin
author_facet Rui, Zhong
Qingling, Chen
Xinyue, Zhang
Xin, Zhang
Weihong, Lin
author_sort Rui, Zhong
collection PubMed
description BACKGROUND: Sleep benefit (SB) refers to the poorly understood phenomenon in Parkinson’s disease (PD) in which patients wake up in the morning with improved motor function. Although previous studies have suggested that several related factors are associated with SB, this relationship remains controversial. OBJECTIVE: This systematic review and meta-analysis aimed to identify the possible related factors of SB in PD. METHODS: We searched PubMed, EMBASE and WanFang databases to collect eligible articles. We calculated pooled estimates of odds ratios (ORs) or the mean deviation (MD) with 95% confidence intervals. RESULTS: We found 3 related factors associated with SB: the duration of PD (MD 1.22, 95% CI: 0.21–2.23), sleep efficiency (MD -4.48,95% CI: -7.24- -2.44), and on-state MDS-UPDRS-Ⅲ total score (MD 3.05, 95% CI: 0.53–5.57). CONCLUSION: PD patients with SB are more likely to have a long duration of PD, a low sleep efficiency and a high MDS-UPDRS-Ⅲ total score. Our work helps obtain a better understanding of sleep SB in PD and its underlying mechanisms. More studies need to be conducted to evaluate the associations between clinical factors in PD and the SB phenomenon.
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spelling pubmed-64111082019-04-01 The related factors of sleep benefit in Parkinson’s disease: A systematic review and meta-analysis Rui, Zhong Qingling, Chen Xinyue, Zhang Xin, Zhang Weihong, Lin PLoS One Research Article BACKGROUND: Sleep benefit (SB) refers to the poorly understood phenomenon in Parkinson’s disease (PD) in which patients wake up in the morning with improved motor function. Although previous studies have suggested that several related factors are associated with SB, this relationship remains controversial. OBJECTIVE: This systematic review and meta-analysis aimed to identify the possible related factors of SB in PD. METHODS: We searched PubMed, EMBASE and WanFang databases to collect eligible articles. We calculated pooled estimates of odds ratios (ORs) or the mean deviation (MD) with 95% confidence intervals. RESULTS: We found 3 related factors associated with SB: the duration of PD (MD 1.22, 95% CI: 0.21–2.23), sleep efficiency (MD -4.48,95% CI: -7.24- -2.44), and on-state MDS-UPDRS-Ⅲ total score (MD 3.05, 95% CI: 0.53–5.57). CONCLUSION: PD patients with SB are more likely to have a long duration of PD, a low sleep efficiency and a high MDS-UPDRS-Ⅲ total score. Our work helps obtain a better understanding of sleep SB in PD and its underlying mechanisms. More studies need to be conducted to evaluate the associations between clinical factors in PD and the SB phenomenon. Public Library of Science 2019-03-11 /pmc/articles/PMC6411108/ /pubmed/30856190 http://dx.doi.org/10.1371/journal.pone.0212951 Text en © 2019 Rui et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Rui, Zhong
Qingling, Chen
Xinyue, Zhang
Xin, Zhang
Weihong, Lin
The related factors of sleep benefit in Parkinson’s disease: A systematic review and meta-analysis
title The related factors of sleep benefit in Parkinson’s disease: A systematic review and meta-analysis
title_full The related factors of sleep benefit in Parkinson’s disease: A systematic review and meta-analysis
title_fullStr The related factors of sleep benefit in Parkinson’s disease: A systematic review and meta-analysis
title_full_unstemmed The related factors of sleep benefit in Parkinson’s disease: A systematic review and meta-analysis
title_short The related factors of sleep benefit in Parkinson’s disease: A systematic review and meta-analysis
title_sort related factors of sleep benefit in parkinson’s disease: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411108/
https://www.ncbi.nlm.nih.gov/pubmed/30856190
http://dx.doi.org/10.1371/journal.pone.0212951
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