Overexpression of wbkF gene in Brucella abortus RB51WboA leads to increased O-polysaccharide expression and enhanced vaccine efficacy against B. abortus 2308, B. melitensis 16M, and B. suis 1330 in a murine brucellosis model

Brucella abortus RB51 is an attenuated, stable, spontaneous rough mutant derived in the laboratory from the virulent strain B. abortus 2308. Previous studies discovered that the wboA gene, which encodes a glycosyltransferase required for synthesis of the O-polysaccharide, is disrupted in strain RB51...

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Detalles Bibliográficos
Autores principales: Dabral, Neha, Burcham, Grant N., Jain-Gupta, Neeta, Sriranganathan, Nammalwar, Vemulapalli, Ramesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411116/
https://www.ncbi.nlm.nih.gov/pubmed/30856219
http://dx.doi.org/10.1371/journal.pone.0213587

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