Calpain Inhibition Restores Autophagy and Prevents Mitochondrial Fragmentation in a Human iPSC Model of Diabetic Endotheliopathy

The relationship between diabetes and endothelial dysfunction remains unclear, particularly the association with pathological activation of calpain, an intracellular cysteine protease. Here, we used human induced pluripotent stem cells-derived endothelial cells (iPSC-ECs) to investigate the effects...

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Detalles Bibliográficos
Autores principales: Ong, Sang-Bing, Lee, Won Hee, Shao, Ning-Yi, Ismail, Nur Izzah, Katwadi, Khairunnisa, Lim, Mim-Mim, Kwek, Xiu-Yi, Michel, Nathaly Anto, Li, Jiajun, Newson, Jordan, Tahmasebi, Soroush, Rehman, Jalees, Kodo, Kazuki, Jang, Hye Ryoun, Ong, Sang-Ging
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411483/
https://www.ncbi.nlm.nih.gov/pubmed/30799273
http://dx.doi.org/10.1016/j.stemcr.2019.01.017

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