Systemic adverse events in imiquimod use for cervical intraepithelial neoplasia – A case series

Treatment for cervical intraepithelial neoplasia (CIN) often consists of an excisional procedure. However, less invasive treatment methods have been explored, such as topical treatment with imiquimod cream. Imiquimod has been proven to be effective in the regression of vulvar intraepithelial neoplas...

Descripción completa

Detalles Bibliográficos
Autores principales: Wouters, Tirza, Hendriks, Natasja, Koeneman, Margot, Kruse, Arnold-Jan, van de Sande, Anna, van Beekhuizen, Heleen J., Gerestein, Kees G., Bekkers, Ruud L.M., Piek, Jurgen M.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411488/
https://www.ncbi.nlm.nih.gov/pubmed/30906696
http://dx.doi.org/10.1016/j.crwh.2019.e00105
_version_ 1783402392595726336
author Wouters, Tirza
Hendriks, Natasja
Koeneman, Margot
Kruse, Arnold-Jan
van de Sande, Anna
van Beekhuizen, Heleen J.
Gerestein, Kees G.
Bekkers, Ruud L.M.
Piek, Jurgen M.J.
author_facet Wouters, Tirza
Hendriks, Natasja
Koeneman, Margot
Kruse, Arnold-Jan
van de Sande, Anna
van Beekhuizen, Heleen J.
Gerestein, Kees G.
Bekkers, Ruud L.M.
Piek, Jurgen M.J.
author_sort Wouters, Tirza
collection PubMed
description Treatment for cervical intraepithelial neoplasia (CIN) often consists of an excisional procedure. However, less invasive treatment methods have been explored, such as topical treatment with imiquimod cream. Imiquimod has been proven to be effective in the regression of vulvar intraepithelial neoplasia (VIN) and vaginal intraepithelial neoplasia (VAIN). Previous studies have investigated the effect of imiquimod in CIN and showed well tolerated adverse effects. During a current study in the Netherlands, a number of adverse events have occurred. This case series presents a selection of these. Gynaecologists should be aware of the possible adverse effects of topical treatment with imiquimod cream.
format Online
Article
Text
id pubmed-6411488
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-64114882019-03-22 Systemic adverse events in imiquimod use for cervical intraepithelial neoplasia – A case series Wouters, Tirza Hendriks, Natasja Koeneman, Margot Kruse, Arnold-Jan van de Sande, Anna van Beekhuizen, Heleen J. Gerestein, Kees G. Bekkers, Ruud L.M. Piek, Jurgen M.J. Case Rep Womens Health Article Treatment for cervical intraepithelial neoplasia (CIN) often consists of an excisional procedure. However, less invasive treatment methods have been explored, such as topical treatment with imiquimod cream. Imiquimod has been proven to be effective in the regression of vulvar intraepithelial neoplasia (VIN) and vaginal intraepithelial neoplasia (VAIN). Previous studies have investigated the effect of imiquimod in CIN and showed well tolerated adverse effects. During a current study in the Netherlands, a number of adverse events have occurred. This case series presents a selection of these. Gynaecologists should be aware of the possible adverse effects of topical treatment with imiquimod cream. Elsevier 2019-03-06 /pmc/articles/PMC6411488/ /pubmed/30906696 http://dx.doi.org/10.1016/j.crwh.2019.e00105 Text en © 2019 The Authors. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Wouters, Tirza
Hendriks, Natasja
Koeneman, Margot
Kruse, Arnold-Jan
van de Sande, Anna
van Beekhuizen, Heleen J.
Gerestein, Kees G.
Bekkers, Ruud L.M.
Piek, Jurgen M.J.
Systemic adverse events in imiquimod use for cervical intraepithelial neoplasia – A case series
title Systemic adverse events in imiquimod use for cervical intraepithelial neoplasia – A case series
title_full Systemic adverse events in imiquimod use for cervical intraepithelial neoplasia – A case series
title_fullStr Systemic adverse events in imiquimod use for cervical intraepithelial neoplasia – A case series
title_full_unstemmed Systemic adverse events in imiquimod use for cervical intraepithelial neoplasia – A case series
title_short Systemic adverse events in imiquimod use for cervical intraepithelial neoplasia – A case series
title_sort systemic adverse events in imiquimod use for cervical intraepithelial neoplasia – a case series
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411488/
https://www.ncbi.nlm.nih.gov/pubmed/30906696
http://dx.doi.org/10.1016/j.crwh.2019.e00105
work_keys_str_mv AT wouterstirza systemicadverseeventsinimiquimoduseforcervicalintraepithelialneoplasiaacaseseries
AT hendriksnatasja systemicadverseeventsinimiquimoduseforcervicalintraepithelialneoplasiaacaseseries
AT koenemanmargot systemicadverseeventsinimiquimoduseforcervicalintraepithelialneoplasiaacaseseries
AT krusearnoldjan systemicadverseeventsinimiquimoduseforcervicalintraepithelialneoplasiaacaseseries
AT vandesandeanna systemicadverseeventsinimiquimoduseforcervicalintraepithelialneoplasiaacaseseries
AT vanbeekhuizenheleenj systemicadverseeventsinimiquimoduseforcervicalintraepithelialneoplasiaacaseseries
AT geresteinkeesg systemicadverseeventsinimiquimoduseforcervicalintraepithelialneoplasiaacaseseries
AT bekkersruudlm systemicadverseeventsinimiquimoduseforcervicalintraepithelialneoplasiaacaseseries
AT piekjurgenmj systemicadverseeventsinimiquimoduseforcervicalintraepithelialneoplasiaacaseseries

Ejemplares similares