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Large-scale brain functional network topology disruptions underlie symptom heterogeneity in children with attention-deficit/hyperactivity disorder

Accumulating evidence suggests brain network dysfunction in attention-deficit/hyperactivity disorder (ADHD). Whether large-scale brain network connectivity patterns reflect clinical heterogeneity in ADHD remains to be fully understood. This study aimed to characterize the differential within- and be...

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Autores principales: Qian, Xing, Castellanos, Francisco Xavier, Uddin, Lucina Q., Loo, Beatrice Rui Yi, Liu, Siwei, Koh, Hui Li, Poh, Xue Wei Wendy, Fung, Daniel, Guan, Cuntai, Lee, Tih-Shih, Lim, Choon Guan, Zhou, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411599/
https://www.ncbi.nlm.nih.gov/pubmed/30472167
http://dx.doi.org/10.1016/j.nicl.2018.11.010
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author Qian, Xing
Castellanos, Francisco Xavier
Uddin, Lucina Q.
Loo, Beatrice Rui Yi
Liu, Siwei
Koh, Hui Li
Poh, Xue Wei Wendy
Fung, Daniel
Guan, Cuntai
Lee, Tih-Shih
Lim, Choon Guan
Zhou, Juan
author_facet Qian, Xing
Castellanos, Francisco Xavier
Uddin, Lucina Q.
Loo, Beatrice Rui Yi
Liu, Siwei
Koh, Hui Li
Poh, Xue Wei Wendy
Fung, Daniel
Guan, Cuntai
Lee, Tih-Shih
Lim, Choon Guan
Zhou, Juan
author_sort Qian, Xing
collection PubMed
description Accumulating evidence suggests brain network dysfunction in attention-deficit/hyperactivity disorder (ADHD). Whether large-scale brain network connectivity patterns reflect clinical heterogeneity in ADHD remains to be fully understood. This study aimed to characterize the differential within- and between-network functional connectivity (FC) changes in children with ADHD combined (ADHD-C) or inattentive (ADHD-I) subtypes and their associations with ADHD symptoms. We studied the task-free functional magnetic resonance imaging (fMRI) data of 58 boys with ADHD and 28 demographically matched healthy controls. We measured within- and between-network connectivity of both low-level (sensorimotor) and high-level (cognitive) large-scale intrinsic connectivity networks and network modularity. We found that children with ADHD-C but not those with ADHD-I exhibited hyper-connectivity within the anterior default mode network (DMN) compared with controls. Additionally, children with ADHD-C had higher inter-network FC between the left executive control (ECN) and the salience (SN) networks, between subcortical and visual networks, and between the DMN and left auditory networks than controls, while children with ADHD-I did not show differences compared with controls. Similarly, children with ADHD-C but not ADHD-I showed lower network modularity compared with controls. Importantly, these observed abnormal inter-network connectivity and network modularity metrics were associated with Child Behavioral Checklist (CBCL) attention-deficit/hyperactivity problems and internalizing problems in children with ADHD. This study revealed relatively greater loss of brain functional network segregation in childhood ADHD combined subtype compared to the inattentive subtype, suggesting differential large-scale functional brain network topology phenotype underlying childhood ADHD heterogeneity.
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spelling pubmed-64115992019-03-22 Large-scale brain functional network topology disruptions underlie symptom heterogeneity in children with attention-deficit/hyperactivity disorder Qian, Xing Castellanos, Francisco Xavier Uddin, Lucina Q. Loo, Beatrice Rui Yi Liu, Siwei Koh, Hui Li Poh, Xue Wei Wendy Fung, Daniel Guan, Cuntai Lee, Tih-Shih Lim, Choon Guan Zhou, Juan Neuroimage Clin Article Accumulating evidence suggests brain network dysfunction in attention-deficit/hyperactivity disorder (ADHD). Whether large-scale brain network connectivity patterns reflect clinical heterogeneity in ADHD remains to be fully understood. This study aimed to characterize the differential within- and between-network functional connectivity (FC) changes in children with ADHD combined (ADHD-C) or inattentive (ADHD-I) subtypes and their associations with ADHD symptoms. We studied the task-free functional magnetic resonance imaging (fMRI) data of 58 boys with ADHD and 28 demographically matched healthy controls. We measured within- and between-network connectivity of both low-level (sensorimotor) and high-level (cognitive) large-scale intrinsic connectivity networks and network modularity. We found that children with ADHD-C but not those with ADHD-I exhibited hyper-connectivity within the anterior default mode network (DMN) compared with controls. Additionally, children with ADHD-C had higher inter-network FC between the left executive control (ECN) and the salience (SN) networks, between subcortical and visual networks, and between the DMN and left auditory networks than controls, while children with ADHD-I did not show differences compared with controls. Similarly, children with ADHD-C but not ADHD-I showed lower network modularity compared with controls. Importantly, these observed abnormal inter-network connectivity and network modularity metrics were associated with Child Behavioral Checklist (CBCL) attention-deficit/hyperactivity problems and internalizing problems in children with ADHD. This study revealed relatively greater loss of brain functional network segregation in childhood ADHD combined subtype compared to the inattentive subtype, suggesting differential large-scale functional brain network topology phenotype underlying childhood ADHD heterogeneity. Elsevier 2018-11-19 /pmc/articles/PMC6411599/ /pubmed/30472167 http://dx.doi.org/10.1016/j.nicl.2018.11.010 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Qian, Xing
Castellanos, Francisco Xavier
Uddin, Lucina Q.
Loo, Beatrice Rui Yi
Liu, Siwei
Koh, Hui Li
Poh, Xue Wei Wendy
Fung, Daniel
Guan, Cuntai
Lee, Tih-Shih
Lim, Choon Guan
Zhou, Juan
Large-scale brain functional network topology disruptions underlie symptom heterogeneity in children with attention-deficit/hyperactivity disorder
title Large-scale brain functional network topology disruptions underlie symptom heterogeneity in children with attention-deficit/hyperactivity disorder
title_full Large-scale brain functional network topology disruptions underlie symptom heterogeneity in children with attention-deficit/hyperactivity disorder
title_fullStr Large-scale brain functional network topology disruptions underlie symptom heterogeneity in children with attention-deficit/hyperactivity disorder
title_full_unstemmed Large-scale brain functional network topology disruptions underlie symptom heterogeneity in children with attention-deficit/hyperactivity disorder
title_short Large-scale brain functional network topology disruptions underlie symptom heterogeneity in children with attention-deficit/hyperactivity disorder
title_sort large-scale brain functional network topology disruptions underlie symptom heterogeneity in children with attention-deficit/hyperactivity disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411599/
https://www.ncbi.nlm.nih.gov/pubmed/30472167
http://dx.doi.org/10.1016/j.nicl.2018.11.010
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