Structural investigation of Rett-inducing MeCP2 mutations()

X-ray structure of methyl-CpG binding domain (MBD) of MeCP2, an intrinsically disordered protein (IDP) involved in Rett syndrome, offers a rational basis for defining the spatial distribution for most of the sites where mutations responsible of Rett syndrome, RTT, occur. We have ascribed pathogenici...

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Detalles Bibliográficos
Autores principales: Spiga, Ottavia, Gardini, Simone, Rossi, Nicole, Cicaloni, Vittoria, Pettini, Francesco, Niccolai, Neri, Santucci, Annalisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411616/
https://www.ncbi.nlm.nih.gov/pubmed/30906830
http://dx.doi.org/10.1016/j.gendis.2018.09.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411616/
https://www.ncbi.nlm.nih.gov/pubmed/30906830
http://dx.doi.org/10.1016/j.gendis.2018.09.005

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