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Circular RNAs in Cancer
Circular RNAs (circRNAs) are a class of single-stranded closed RNA molecules that are formed by precursor mRNA back-splicing or skipping events of thousands of genes in eukaryotes as covalently closed continuous loops. High-throughput sequencing and bioinformatics approaches have uncovered the broad...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411617/ https://www.ncbi.nlm.nih.gov/pubmed/30861414 http://dx.doi.org/10.1016/j.omtn.2019.02.005 |
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author | Bach, Duc-Hiep Lee, Sang Kook Sood, Anil K. |
author_facet | Bach, Duc-Hiep Lee, Sang Kook Sood, Anil K. |
author_sort | Bach, Duc-Hiep |
collection | PubMed |
description | Circular RNAs (circRNAs) are a class of single-stranded closed RNA molecules that are formed by precursor mRNA back-splicing or skipping events of thousands of genes in eukaryotes as covalently closed continuous loops. High-throughput sequencing and bioinformatics approaches have uncovered the broad expression of circRNAs across species. Their high stability, abundance, and evolutionary conservation among species points to their distinct properties and diverse cellular functions as efficient microRNAs and protein sponges; they also play important roles in modulating transcription and splicing. Additionally, most circRNAs are aberrantly expressed in pathological conditions and in a tissue-specific manner such as development and progression of cancer. Herein, we highlight the characteristics, functions, and mechanisms of action of circRNAs in cancer; we also provide an overview of recent progress in the circRNA field and future application of circRNAs as cancer biomarkers and novel therapeutic targets. |
format | Online Article Text |
id | pubmed-6411617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | American Society of Gene & Cell Therapy |
record_format | MEDLINE/PubMed |
spelling | pubmed-64116172019-03-22 Circular RNAs in Cancer Bach, Duc-Hiep Lee, Sang Kook Sood, Anil K. Mol Ther Nucleic Acids Article Circular RNAs (circRNAs) are a class of single-stranded closed RNA molecules that are formed by precursor mRNA back-splicing or skipping events of thousands of genes in eukaryotes as covalently closed continuous loops. High-throughput sequencing and bioinformatics approaches have uncovered the broad expression of circRNAs across species. Their high stability, abundance, and evolutionary conservation among species points to their distinct properties and diverse cellular functions as efficient microRNAs and protein sponges; they also play important roles in modulating transcription and splicing. Additionally, most circRNAs are aberrantly expressed in pathological conditions and in a tissue-specific manner such as development and progression of cancer. Herein, we highlight the characteristics, functions, and mechanisms of action of circRNAs in cancer; we also provide an overview of recent progress in the circRNA field and future application of circRNAs as cancer biomarkers and novel therapeutic targets. American Society of Gene & Cell Therapy 2019-02-16 /pmc/articles/PMC6411617/ /pubmed/30861414 http://dx.doi.org/10.1016/j.omtn.2019.02.005 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Bach, Duc-Hiep Lee, Sang Kook Sood, Anil K. Circular RNAs in Cancer |
title | Circular RNAs in Cancer |
title_full | Circular RNAs in Cancer |
title_fullStr | Circular RNAs in Cancer |
title_full_unstemmed | Circular RNAs in Cancer |
title_short | Circular RNAs in Cancer |
title_sort | circular rnas in cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411617/ https://www.ncbi.nlm.nih.gov/pubmed/30861414 http://dx.doi.org/10.1016/j.omtn.2019.02.005 |
work_keys_str_mv | AT bachduchiep circularrnasincancer AT leesangkook circularrnasincancer AT soodanilk circularrnasincancer |