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Circular RNAs in Cancer

Circular RNAs (circRNAs) are a class of single-stranded closed RNA molecules that are formed by precursor mRNA back-splicing or skipping events of thousands of genes in eukaryotes as covalently closed continuous loops. High-throughput sequencing and bioinformatics approaches have uncovered the broad...

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Autores principales: Bach, Duc-Hiep, Lee, Sang Kook, Sood, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411617/
https://www.ncbi.nlm.nih.gov/pubmed/30861414
http://dx.doi.org/10.1016/j.omtn.2019.02.005
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author Bach, Duc-Hiep
Lee, Sang Kook
Sood, Anil K.
author_facet Bach, Duc-Hiep
Lee, Sang Kook
Sood, Anil K.
author_sort Bach, Duc-Hiep
collection PubMed
description Circular RNAs (circRNAs) are a class of single-stranded closed RNA molecules that are formed by precursor mRNA back-splicing or skipping events of thousands of genes in eukaryotes as covalently closed continuous loops. High-throughput sequencing and bioinformatics approaches have uncovered the broad expression of circRNAs across species. Their high stability, abundance, and evolutionary conservation among species points to their distinct properties and diverse cellular functions as efficient microRNAs and protein sponges; they also play important roles in modulating transcription and splicing. Additionally, most circRNAs are aberrantly expressed in pathological conditions and in a tissue-specific manner such as development and progression of cancer. Herein, we highlight the characteristics, functions, and mechanisms of action of circRNAs in cancer; we also provide an overview of recent progress in the circRNA field and future application of circRNAs as cancer biomarkers and novel therapeutic targets.
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spelling pubmed-64116172019-03-22 Circular RNAs in Cancer Bach, Duc-Hiep Lee, Sang Kook Sood, Anil K. Mol Ther Nucleic Acids Article Circular RNAs (circRNAs) are a class of single-stranded closed RNA molecules that are formed by precursor mRNA back-splicing or skipping events of thousands of genes in eukaryotes as covalently closed continuous loops. High-throughput sequencing and bioinformatics approaches have uncovered the broad expression of circRNAs across species. Their high stability, abundance, and evolutionary conservation among species points to their distinct properties and diverse cellular functions as efficient microRNAs and protein sponges; they also play important roles in modulating transcription and splicing. Additionally, most circRNAs are aberrantly expressed in pathological conditions and in a tissue-specific manner such as development and progression of cancer. Herein, we highlight the characteristics, functions, and mechanisms of action of circRNAs in cancer; we also provide an overview of recent progress in the circRNA field and future application of circRNAs as cancer biomarkers and novel therapeutic targets. American Society of Gene & Cell Therapy 2019-02-16 /pmc/articles/PMC6411617/ /pubmed/30861414 http://dx.doi.org/10.1016/j.omtn.2019.02.005 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Bach, Duc-Hiep
Lee, Sang Kook
Sood, Anil K.
Circular RNAs in Cancer
title Circular RNAs in Cancer
title_full Circular RNAs in Cancer
title_fullStr Circular RNAs in Cancer
title_full_unstemmed Circular RNAs in Cancer
title_short Circular RNAs in Cancer
title_sort circular rnas in cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411617/
https://www.ncbi.nlm.nih.gov/pubmed/30861414
http://dx.doi.org/10.1016/j.omtn.2019.02.005
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