Emerging roles of lncRNAs in the post-transcriptional regulation in cancer

Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can play a pivotal role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master gene regulators at transcriptional and posttranscriptional levels, leading to tumorigenesis. In this review, we discuss...

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Autores principales: He, Rong-Zhang, Luo, Di-Xian, Mo, Yin-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411652/
https://www.ncbi.nlm.nih.gov/pubmed/30906827
http://dx.doi.org/10.1016/j.gendis.2019.01.003
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author He, Rong-Zhang
Luo, Di-Xian
Mo, Yin-Yuan
author_facet He, Rong-Zhang
Luo, Di-Xian
Mo, Yin-Yuan
author_sort He, Rong-Zhang
collection PubMed
description Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can play a pivotal role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master gene regulators at transcriptional and posttranscriptional levels, leading to tumorigenesis. In this review, we discuss latest developments in lncRNA-meditated gene expression at the post-transcriptional level, including gene splicing, mRNA stability, protein stability and nuclear trafficking.
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spelling pubmed-64116522019-03-22 Emerging roles of lncRNAs in the post-transcriptional regulation in cancer He, Rong-Zhang Luo, Di-Xian Mo, Yin-Yuan Genes Dis Article Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can play a pivotal role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master gene regulators at transcriptional and posttranscriptional levels, leading to tumorigenesis. In this review, we discuss latest developments in lncRNA-meditated gene expression at the post-transcriptional level, including gene splicing, mRNA stability, protein stability and nuclear trafficking. Chongqing Medical University 2019-02-11 /pmc/articles/PMC6411652/ /pubmed/30906827 http://dx.doi.org/10.1016/j.gendis.2019.01.003 Text en © 2019 Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
He, Rong-Zhang
Luo, Di-Xian
Mo, Yin-Yuan
Emerging roles of lncRNAs in the post-transcriptional regulation in cancer
title Emerging roles of lncRNAs in the post-transcriptional regulation in cancer
title_full Emerging roles of lncRNAs in the post-transcriptional regulation in cancer
title_fullStr Emerging roles of lncRNAs in the post-transcriptional regulation in cancer
title_full_unstemmed Emerging roles of lncRNAs in the post-transcriptional regulation in cancer
title_short Emerging roles of lncRNAs in the post-transcriptional regulation in cancer
title_sort emerging roles of lncrnas in the post-transcriptional regulation in cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411652/
https://www.ncbi.nlm.nih.gov/pubmed/30906827
http://dx.doi.org/10.1016/j.gendis.2019.01.003
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