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Quality of life and voice outcome of patients treated with transoral CO(2) laser microsurgery for early glottic carcinoma (T1–T2): a 2-year follow-up study
PURPOSE: Longitudinal studies in laryngeal cancer can provide clinicians information about short-term and long-term functional outcomes, like quality of life (QoL) and voice outcome. This information is important when counseling patients or choosing a primary treatment modality. The present study as...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411677/ https://www.ncbi.nlm.nih.gov/pubmed/30810819 http://dx.doi.org/10.1007/s00405-019-05348-1 |
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author | Hendriksma, Martine van Loon, Yda Klop, W. Martin C. Hakkesteegt, Marieke M. Heijnen, Bas J. el Hasnaoui, Ibtissam de Jong, Martin Langeveld, Ton P. M. van Benthem, Peter Paul G. Baatenburg de Jong, Robert J. Sjögren, Elisabeth V. |
author_facet | Hendriksma, Martine van Loon, Yda Klop, W. Martin C. Hakkesteegt, Marieke M. Heijnen, Bas J. el Hasnaoui, Ibtissam de Jong, Martin Langeveld, Ton P. M. van Benthem, Peter Paul G. Baatenburg de Jong, Robert J. Sjögren, Elisabeth V. |
author_sort | Hendriksma, Martine |
collection | PubMed |
description | PURPOSE: Longitudinal studies in laryngeal cancer can provide clinicians information about short-term and long-term functional outcomes, like quality of life (QoL) and voice outcome. This information is important when counseling patients or choosing a primary treatment modality. The present study assessed long-term (2 years) QoL and voice outcome in patients with extended T1 and limited T2 glottic carcinoma treated with transoral CO(2) laser microsurgery (TLM) (unilateral type III or bilateral type II resections). METHODS: Three questionnaires were administered: the Voice Handicap Index (VHI), the European Organization for Research and Treatment of Cancer (EORTC) QoL questionnaire (QLQ)-C30, the EORTC QLQ-HN35. A perceptual voice evaluation at six different time points was conducted: preoperatively, and postoperatively at 6 weeks, 3 months, 6 months, 1 year, and 2 years. Fluctuations over time were investigated. RESULTS: Sixty-one patients were included in the analysis. Patients reported high-level functioning and low symptom scores 2 years postoperatively. Gender significantly affected the VHI scores at 2 years (mean VHI scores: female 8.7 vs. male, 23.9; p = 0.023). The major improvement in VHI scores was observed within the first 6 months. The tumor stage (T1a, T1b, and T2) significantly impacted the grade (mean scores at 2 years: 1.0, 1.9, and 1.7; p = 0.001). These scores stabilized at 6 months. CONCLUSIONS: Patients show good long-term QoL with low symptom scores, a low voice handicap, and mild to moderate dysphonia, 2 years postoperatively. Scores stabilize at 6 months and provide a clear indication of status at 1 and 2 years. |
format | Online Article Text |
id | pubmed-6411677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-64116772019-04-03 Quality of life and voice outcome of patients treated with transoral CO(2) laser microsurgery for early glottic carcinoma (T1–T2): a 2-year follow-up study Hendriksma, Martine van Loon, Yda Klop, W. Martin C. Hakkesteegt, Marieke M. Heijnen, Bas J. el Hasnaoui, Ibtissam de Jong, Martin Langeveld, Ton P. M. van Benthem, Peter Paul G. Baatenburg de Jong, Robert J. Sjögren, Elisabeth V. Eur Arch Otorhinolaryngol Laryngology PURPOSE: Longitudinal studies in laryngeal cancer can provide clinicians information about short-term and long-term functional outcomes, like quality of life (QoL) and voice outcome. This information is important when counseling patients or choosing a primary treatment modality. The present study assessed long-term (2 years) QoL and voice outcome in patients with extended T1 and limited T2 glottic carcinoma treated with transoral CO(2) laser microsurgery (TLM) (unilateral type III or bilateral type II resections). METHODS: Three questionnaires were administered: the Voice Handicap Index (VHI), the European Organization for Research and Treatment of Cancer (EORTC) QoL questionnaire (QLQ)-C30, the EORTC QLQ-HN35. A perceptual voice evaluation at six different time points was conducted: preoperatively, and postoperatively at 6 weeks, 3 months, 6 months, 1 year, and 2 years. Fluctuations over time were investigated. RESULTS: Sixty-one patients were included in the analysis. Patients reported high-level functioning and low symptom scores 2 years postoperatively. Gender significantly affected the VHI scores at 2 years (mean VHI scores: female 8.7 vs. male, 23.9; p = 0.023). The major improvement in VHI scores was observed within the first 6 months. The tumor stage (T1a, T1b, and T2) significantly impacted the grade (mean scores at 2 years: 1.0, 1.9, and 1.7; p = 0.001). These scores stabilized at 6 months. CONCLUSIONS: Patients show good long-term QoL with low symptom scores, a low voice handicap, and mild to moderate dysphonia, 2 years postoperatively. Scores stabilize at 6 months and provide a clear indication of status at 1 and 2 years. Springer Berlin Heidelberg 2019-02-27 2019 /pmc/articles/PMC6411677/ /pubmed/30810819 http://dx.doi.org/10.1007/s00405-019-05348-1 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Laryngology Hendriksma, Martine van Loon, Yda Klop, W. Martin C. Hakkesteegt, Marieke M. Heijnen, Bas J. el Hasnaoui, Ibtissam de Jong, Martin Langeveld, Ton P. M. van Benthem, Peter Paul G. Baatenburg de Jong, Robert J. Sjögren, Elisabeth V. Quality of life and voice outcome of patients treated with transoral CO(2) laser microsurgery for early glottic carcinoma (T1–T2): a 2-year follow-up study |
title | Quality of life and voice outcome of patients treated with transoral CO(2) laser microsurgery for early glottic carcinoma (T1–T2): a 2-year follow-up study |
title_full | Quality of life and voice outcome of patients treated with transoral CO(2) laser microsurgery for early glottic carcinoma (T1–T2): a 2-year follow-up study |
title_fullStr | Quality of life and voice outcome of patients treated with transoral CO(2) laser microsurgery for early glottic carcinoma (T1–T2): a 2-year follow-up study |
title_full_unstemmed | Quality of life and voice outcome of patients treated with transoral CO(2) laser microsurgery for early glottic carcinoma (T1–T2): a 2-year follow-up study |
title_short | Quality of life and voice outcome of patients treated with transoral CO(2) laser microsurgery for early glottic carcinoma (T1–T2): a 2-year follow-up study |
title_sort | quality of life and voice outcome of patients treated with transoral co(2) laser microsurgery for early glottic carcinoma (t1–t2): a 2-year follow-up study |
topic | Laryngology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411677/ https://www.ncbi.nlm.nih.gov/pubmed/30810819 http://dx.doi.org/10.1007/s00405-019-05348-1 |
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