Cargando…

Trimetazidine Attenuates Exhaustive Exercise-Induced Myocardial Injury in Rats via Regulation of the Nrf2/NF-κB Signaling Pathway

Exhausted exercise has been reported to cause the damage of myocardial structure and function in terms of cardiomyocyte apoptosis, oxidative stress, and energy metabolism disturbance. Trimetazidine (TMZ), as an anti-ischemic agent, has been approved to be effective in promoting myocardial energy met...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Hongming, Liu, Moyan, Zhang, Yuyan, Li, Xiaoyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411712/ https://www.ncbi.nlm.nih.gov/pubmed/30890937 http://dx.doi.org/10.3389/fphar.2019.00175

Ejemplares similares

Trimetazidine Attenuates Heart Failure by Improving Myocardial Metabolism via AMPK
por: Shu, Hongyang, et al.
Publicado: (2021)

Trimetazidine in Heart Failure
por: Shu, Hongyang, et al.
Publicado: (2021)

Black Truffle Aqueous Extract Attenuates Oxidative Stress and Inflammation in STZ-Induced Hyperglycemic Rats via Nrf2 and NF-κB Pathways
por: Zhang, Tongze, et al.
Publicado: (2018)

Chelerythrine Attenuates the Inflammation of Lipopolysaccharide-Induced Acute Lung Inflammation Through NF-κB Signaling Pathway Mediated by Nrf2
por: Fan, Lu, et al.
Publicado: (2018)

Sanguinarine protects against indomethacin-induced small intestine injury in rats by regulating the Nrf2/NF-κB pathways
por: Lin, Xiu-lian, et al.
Publicado: (2022)

Isoliquiritigenin Inhibits Cigarette Smoke-Induced COPD by Attenuating Inflammation and Oxidative Stress via the Regulation of the Nrf2 and NF-κB Signaling Pathways
por: Yu, Duo, et al.
Publicado: (2018)

Cycloastragenol Attenuates Osteoclastogenesis and Bone Loss by Targeting RANKL-Induced Nrf2/Keap1/ARE, NF-κB, Calcium, and NFATc1 Pathways
por: Wang, Gang, et al.
Publicado: (2022)

Trimetazidine Ameliorates Myocardial Metabolic Remodeling in Isoproterenol-Induced Rats Through Regulating Ketone Body Metabolism via Activating AMPK and PPAR α
por: Li, Huihui, et al.
Publicado: (2020)

Triptriolide Alleviates Lipopolysaccharide-Induced Liver Injury by Nrf2 and NF-κB Signaling Pathways
por: Yang, Yi-Qi, et al.
Publicado: (2018)

Chanling Gao Attenuates Bone Cancer Pain in Rats by the IKKβ/NF-κB Signaling Pathway
por: Yang, Bing, et al.
Publicado: (2020)

Trimetazidine Modulates Mitochondrial Redox Status and Disrupted Glutamate Homeostasis in a Rat Model of Epilepsy
por: Al-Shorbagy, Muhammad Y., et al.
Publicado: (2021)

Trilobatin, a Naturally Occurring Food Additive, Ameliorates Exhaustive Exercise-Induced Fatigue in Mice: Involvement of Nrf2/ARE/Ferroptosis Signaling Pathway
por: Xiao, Ran, et al.
Publicado: (2022)

Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo
por: Jiang, Zengxin, et al.
Publicado: (2022)

Angiotensin (1-7) Attenuates Sepsis-Induced Acute Kidney Injury by Regulating the NF-κB Pathway
por: Zhu, Ying, et al.
Publicado: (2021)

Dehydrocorydaline Protects Against Sepsis-Induced Myocardial Injury Through Modulating the TRAF6/NF-κB Pathway
por: Li, Yadong, et al.
Publicado: (2021)

Antihyperalgesic Properties of Honokiol in Inflammatory Pain Models by Targeting of NF-κB and Nrf2 Signaling
por: Khalid, Sidra, et al.
Publicado: (2018)

Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1
por: Yang, Yong, et al.
Publicado: (2020)

Ginkgolide C slows the progression of osteoarthritis by activating Nrf2/HO-1 and blocking the NF-κB pathway
por: Ma, Tianwen, et al.
Publicado: (2022)

2′-O-Galloylhyperin Isolated From Pyrola incarnata Fisch. Attenuates LPS-Induced Inflammatory Response by Activation of SIRT1/Nrf2 and Inhibition of the NF-κB Pathways in Vitro and Vivo
por: Wang, Peng, et al.
Publicado: (2018)

Neferine Attenuates Acute Kidney Injury by Inhibiting NF-κB Signaling and Upregulating Klotho Expression
por: Li, Huihui, et al.
Publicado: (2019)

Shenlian Extract Against Myocardial Injury Induced by Ischemia Through the Regulation of NF-κB/IκB Signaling Axis
por: Guo, Yuan, et al.
Publicado: (2020)

Protective Effects of Pterostilbene on Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting NF-κB and Activating Nrf2/HO-1 Signaling Pathways
por: Zhang, Yong, et al.
Publicado: (2021)

Gastroprotective Effect of Sinapic Acid on Ethanol-Induced Gastric Ulcers in Rats: Involvement of Nrf2/HO-1 and NF-κB Signaling and Antiapoptotic Role
por: Raish, Mohammad, et al.
Publicado: (2021)

Carbocisteine as a Modulator of Nrf2/HO-1 and NFκB Interplay in Rats: New Inspiration for the Revival of an Old Drug for Treating Ulcerative Colitis
por: Abdelhamid, Amir Mohamed, et al.
Publicado: (2022)

Amentoflavone Ameliorates Carrageenan-Induced Pleurisy and Lung Injury by Inhibiting the NF-κB/STAT3 Pathways via Nrf2 Activation
por: Hou, Tianhua, et al.
Publicado: (2022)

Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway
por: Hu, Ji, et al.
Publicado: (2021)

Metabonomic Analysis of the Therapeutic Effects of Chinese Medicine Sanqi Oral Solution on Rats With Exhaustive Exercise
por: Xu, Peng, et al.
Publicado: (2019)

Trimetazidine and exercise offer analogous improvements to the skeletal muscle insulin resistance of mice through Nrf2 signaling
por: Zhang, Wenliang, et al.
Publicado: (2022)

Ginkgolide C Alleviates Myocardial Ischemia/Reperfusion-Induced Inflammatory Injury via Inhibition of CD40-NF-κB Pathway
por: Zhang, Rui, et al.
Publicado: (2018)

Maresin 1 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting NOX4/ROS/NF-κB Pathway
por: Li, Jiameng, et al.
Publicado: (2021)

Phenylethanoid Glycosides From Callicarpa kwangtungensis Chun Attenuate TNF-α-Induced Cell Damage by Inhibiting NF-κB Pathway and Enhancing Nrf2 Pathway in A549 Cells
por: Zheng, Jing-Na, et al.
Publicado: (2021)

Exosomes secreted by FNDC5-BMMSCs protect myocardial infarction by anti-inflammation and macrophage polarization via NF-κB signaling pathway and Nrf2/HO-1 axis
por: Ning, Hongjuan, et al.
Publicado: (2021)

Betulin Alleviates the Inflammatory Response in Mouse Chondrocytes and Ameliorates Osteoarthritis via AKT/Nrf2/HO-1/NF-κB Axis
por: Ren, Chenghao, et al.
Publicado: (2021)

Targeting Cytokine Release Through the Differential Modulation of Nrf2 and NF-κB Pathways by Electrophilic/Non-Electrophilic Compounds
por: Fagiani, Francesca, et al.
Publicado: (2020)

Huangkui lianchang decoction attenuates experimental colitis by inhibiting the NF-κB pathway and autophagy
por: Cheng, Xudong, et al.
Publicado: (2022)

Corrigendum: Dauricine attenuates vascular endothelial inflammation through inhibiting NF-κB pathway
por: Hu, Ji, et al.
Publicado: (2023)

Aspirin Attenuates Cardiac Allograft Rejection by Inhibiting the Maturation of Dendritic Cells via the NF-κB Signaling Pathway
por: Zhang, Xi, et al.
Publicado: (2021)

Targeting Glycogen Synthase Kinase 3 Beta Regulates CD47 Expression After Myocardial Infarction in Rats via the NF-κB Signaling Pathway
por: Xu, Li-Na, et al.
Publicado: (2021)

N-Acetyldopamine Dimer Attenuates DSS-Induced Ulcerative Colitis by Suppressing NF-κB and MAPK Pathways
por: Huang, Li-Jun, et al.
Publicado: (2022)

Poldip2 knockdown protects against lipopolysaccharide-induced acute lung injury via Nox4/Nrf2/NF-κB signaling pathway
por: Wang, Yueguo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pikqg13lgjsu3rea6el9cqu71q