Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders

The use of extracellular vesicles (EVs) as cell free therapy is a promising approach to stimulate tissue regeneration including that of the nervous system. EVs transfer bioactive proteins and lipids, RNA and microRNAs, which play a relevant role in EV-mediated intercellular communication. The immuno...

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Autores principales: Galieva, Luisa R., James, Victoria, Mukhamedshina, Yana O., Rizvanov, Albert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411850/
https://www.ncbi.nlm.nih.gov/pubmed/30890911
http://dx.doi.org/10.3389/fnins.2019.00163
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author Galieva, Luisa R.
James, Victoria
Mukhamedshina, Yana O.
Rizvanov, Albert A.
author_facet Galieva, Luisa R.
James, Victoria
Mukhamedshina, Yana O.
Rizvanov, Albert A.
author_sort Galieva, Luisa R.
collection PubMed
description The use of extracellular vesicles (EVs) as cell free therapy is a promising approach to stimulate tissue regeneration including that of the nervous system. EVs transfer bioactive proteins and lipids, RNA and microRNAs, which play a relevant role in EV-mediated intercellular communication. The immunomodulatory, anti-inflammatory, and neuroprotective effects of mesenchymal stem cells-derived EVs have been well studied, knowledge of this paracrine mechanism and the availability of these cells, positions mesenchymal stem cells as a potential source of EVs for cell free therapy for a variety of regenerative and nervous system disorders. In this review, we focus on the immunomodulatory and neuroprotective effects of stem cells-derived EVs within in vitro and in vivo models of nerve disorders.
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spelling pubmed-64118502019-03-19 Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders Galieva, Luisa R. James, Victoria Mukhamedshina, Yana O. Rizvanov, Albert A. Front Neurosci Neuroscience The use of extracellular vesicles (EVs) as cell free therapy is a promising approach to stimulate tissue regeneration including that of the nervous system. EVs transfer bioactive proteins and lipids, RNA and microRNAs, which play a relevant role in EV-mediated intercellular communication. The immunomodulatory, anti-inflammatory, and neuroprotective effects of mesenchymal stem cells-derived EVs have been well studied, knowledge of this paracrine mechanism and the availability of these cells, positions mesenchymal stem cells as a potential source of EVs for cell free therapy for a variety of regenerative and nervous system disorders. In this review, we focus on the immunomodulatory and neuroprotective effects of stem cells-derived EVs within in vitro and in vivo models of nerve disorders. Frontiers Media S.A. 2019-03-05 /pmc/articles/PMC6411850/ /pubmed/30890911 http://dx.doi.org/10.3389/fnins.2019.00163 Text en Copyright © 2019 Galieva, James, Mukhamedshina and Rizvanov. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Galieva, Luisa R.
James, Victoria
Mukhamedshina, Yana O.
Rizvanov, Albert A.
Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders
title Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders
title_full Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders
title_fullStr Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders
title_full_unstemmed Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders
title_short Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders
title_sort therapeutic potential of extracellular vesicles for the treatment of nerve disorders
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411850/
https://www.ncbi.nlm.nih.gov/pubmed/30890911
http://dx.doi.org/10.3389/fnins.2019.00163
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