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Cargo diffusion shortens single-kinesin runs at low viscous drag

Molecular motors such as kinesin-1 drive active, long-range transport of cargos along microtubules in cells. Thermal diffusion of the cargo can impose a randomly directed, fluctuating mechanical load on the motor carrying the cargo. Recent experiments highlighted a strong asymmetry in the sensitivit...

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Detalles Bibliográficos
Autores principales: Wilson, John O., Quint, David A., Gopinathan, Ajay, Xu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411862/
https://www.ncbi.nlm.nih.gov/pubmed/30858425
http://dx.doi.org/10.1038/s41598-019-40550-5