Cargando…

Low-dose 2-deoxyglucose and metformin synergically inhibit proliferation of human polycystic kidney cells by modulating glucose metabolism

Polycystic kidney disease (PKD) is a common hereditary kidney disease with abnormal proliferation and apoptosis of kidney cystic epithelial cells, eventually leading to chronic renal failure. Currently, there are no effective treatment methods. Similar to tumor cells, cystic epithelial cells have ab...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Jing, Ma, Yuxiang, Zhang, Yingjie, Fu, Bo, Wu, Xiaoyuan, Li, Qinggang, Cai, Guangyan, Chen, Xiangmei, Bai, Xue-Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411866/ https://www.ncbi.nlm.nih.gov/pubmed/30886744 http://dx.doi.org/10.1038/s41420-019-0156-8

Ejemplares similares

Ganab Haploinsufficiency Does Not Cause Polycystic Kidney Disease or Polycystic Liver Disease in Mice
por: Geng, Guangrui, et al.
Publicado: (2020)

Identifying gene mutations of Chinese patients with polycystic kidney disease through targeted next‐generation sequencing technology
por: Wang, Tao, et al.
Publicado: (2019)

Microarray analysis of breast cancer gene expression profiling in response to 2-deoxyglucose, metformin, and glucose starvation
por: Aoun, Rita, et al.
Publicado: (2022)

Suppressor of Cytokine Signaling-1/STAT1 Regulates Renal Inflammation in Mesangial Proliferative Glomerulonephritis Models
por: Bai, Jiuxu, et al.
Publicado: (2018)

GDF11 improves tubular regeneration after acute kidney injury in elderly mice
por: Zhang, Ying, et al.
Publicado: (2016)

ABT-263 Enhances Sensitivity to Metformin and 2-Deoxyglucose in Pediatric Glioma by Promoting Apoptotic Cell Death
por: Levesley, Jane, et al.
Publicado: (2013)

Changes in the Expression of the Toll-Like Receptor System in the Aging Rat Kidneys
por: Xi, Yue, et al.
Publicado: (2014)

Placental Transfer of Lactate, Glucose and 2-deoxyglucose in Control and Diabetic Wistar Rats
por: Thomas, Chris R., et al.
Publicado: (2001)

Activated mesangial cells induce glomerular endothelial cells proliferation in rat anti‐Thy‐1 nephritis through VEGFA/VEGFR2 and Angpt2/Tie2 pathway
por: Zhao, Yinghua, et al.
Publicado: (2021)

System analysis of gene mutations and clinical phenotype in Chinese patients with autosomal-dominant polycystic kidney disease
por: Jin, Meiling, et al.
Publicado: (2016)

Induction of Apoptosis by a Combination of 2-Deoxyglucose and Metformin in Esophageal Squamous Cell Carcinoma by Targeting Cancer Cell Metabolism
por: Shafaee, Abbas, et al.
Publicado: (2019)

2-Deoxyglucose and Newcastle Disease Virus Synergize to Kill Breast Cancer Cells by Inhibition of Glycolysis Pathway Through Glyceraldehyde3-Phosphate Downregulation
por: Al-Shammari, Ahmed Majeed, et al.
Publicado: (2019)

Rapamycin protects against gentamicin-induced acute kidney injury via autophagy in mini-pig models
por: Cui, Jing, et al.
Publicado: (2015)

Primary cilium in kidney development, function and disease
por: Bai, Yunfeng, et al.
Publicado: (2022)

Metformin and erlotinib synergize to inhibit basal breast cancer
por: Lau, Ying-Ka Ingar, et al.
Publicado: (2014)

Metformin in autosomal dominant polycystic kidney disease: experimental hypothesis or clinical fact?
por: Pisani, Antonio, et al.
Publicado: (2018)

Deoxyglucose prevents neurodegeneration in culture by eliminating microglia
por: Vilalta, Anna, et al.
Publicado: (2014)

Mitochondrial Autophagy Involving Renal Injury and Aging Is Modulated by Caloric Intake in Aged Rat Kidneys
por: Cui, Jing, et al.
Publicado: (2013)

Differential Effects of 2-Deoxyglucose and Glucose Deprivation on 4-Hydroxynonenal Dependent Mitochondrial Dysfunction in Primary Neurons
por: Dodson, Matthew, et al.
Publicado: (2022)

Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy
por: Mathews Samuel, Samson, et al.
Publicado: (2019)

Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation
por: Groenendijk, Floris H, et al.
Publicado: (2015)

Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin
por: Xue, Chaojun, et al.
Publicado: (2016)

Metformin does not slow cyst growth in the PCK rat model of polycystic kidney disease
por: Oto, Ozgur A., et al.
Publicado: (2023)

Rescue of 2-Deoxyglucose Side Effects by Ketogenic Diet
por: Voss, Martin, et al.
Publicado: (2018)

2-deoxyglucose transiently inhibits yeast AMPK signaling and triggers glucose transporter endocytosis, potentiating the drug toxicity
por: Laussel, Clotilde, et al.
Publicado: (2022)

Transcriptomic analysis of B cells suggests that CD70 and LY9 may be novel features in patients with systemic lupus erythematosus
por: Liu, Qun, et al.
Publicado: (2023)

Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease
por: Leonhard, Wouter N., et al.
Publicado: (2019)

Effect of metformin therapy on 2-h post-glucose insulin levels in patients of polycystic ovarian syndrome
por: Saxena, Pikee, et al.
Publicado: (2010)

Synergic Effect of Metformin and Everolimus on Mitochondrial Dynamics of Renal Cell Carcinoma
por: Hong, Seong-Hwi, et al.
Publicado: (2022)

A single-arm pilot study of metformin in patients with autosomal dominant polycystic kidney disease
por: Sorohan, Bogdan Marian, et al.
Publicado: (2019)

Metformin attenuates synergic effect of diabetes mellitus and Helicobacter pylori infection on gastric cancer cells proliferation by suppressing PTEN expression
por: Lu, Huibin, et al.
Publicado: (2021)

2-Deoxyglucose and Beta-Hydroxybutyrate: Metabolic Agents for Seizure Control
por: Rho, Jong M., et al.
Publicado: (2019)

‘Sugarcoating’ 2-deoxyglucose: mechanisms that suppress its toxic effects
por: Schmidt, Martin C., et al.
Publicado: (2020)

2-Deoxyglucose, an Inhibitor of Glycolysis, Enhances the Oncolytic Effect of Coxsackievirus
por: Vorobyev, Pavel O., et al.
Publicado: (2022)

Metformin and temozolomide, a synergic option to overcome resistance in glioblastoma multiforme models
por: Valtorta, Silvia, et al.
Publicado: (2017)

Lower starting dose of roxadustat in non-dialysis-dependent chronic kidney disease patients with anaemia: a study protocol for a randomised, multicentre, open-label study
por: Li, Ping, et al.
Publicado: (2023)

Sodium–glucose cotransporter inhibition in polycystic kidney disease: fact or fiction
por: Afsar, Baris, et al.
Publicado: (2022)

Cell cycle synchronisation using thiazolidinediones affects cellular glucose metabolism and enhances the therapeutic effect of 2-deoxyglucose in colon cancer
por: Yoon, Joon-Kee, et al.
Publicado: (2020)

Metformin effects on zonulin level in polycystic ovarian women
por: Ibrahim, Manal, et al.
Publicado: (2020)

Novel method for the genomic analysis of PKD1 mutation in autosomal dominant polycystic kidney disease
por: Shang, Shunlai, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_e0ineerbnpbl9fep1ki130ghsu