The methionine salvage pathway-involving ADI1 inhibits hepatoma growth by epigenetically altering genes expression via elevating S-adenosylmethionine

The 5′-methylthioadenosine (MTA) cycle-participating human acireductone dioxygenase 1 (ADI1) has been implicated as a tumor suppressor in prostate cancer, yet its role remains unclear in hepatocellular carcinoma (HCC). Here, we demonstrated a significant reduction of ADI1, either in protein or mRNA...

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Detalles Bibliográficos
Autores principales: Chu, Yu-De, Lai, Hsin-Yu, Pai, Li-Mei, Huang, Ya-Hui, Lin, Yang-Hsiang, Liang, Kung-Hao, Yeh, Chau-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411897/
https://www.ncbi.nlm.nih.gov/pubmed/30858354
http://dx.doi.org/10.1038/s41419-019-1486-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411897/
https://www.ncbi.nlm.nih.gov/pubmed/30858354
http://dx.doi.org/10.1038/s41419-019-1486-4

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