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Selective sensory deafferentation induces structural and functional brain plasticity

Sensory-motor integration models have been proposed aiming to explain how the brain uses sensory information to guide and check the planning and execution of movements. Sensory neuronopathy (SN) is a peculiar disease characterized by exclusive, severe and widespread sensory loss. It is a valuable co...

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Detalles Bibliográficos
Autores principales: Casseb, Raphael F., de Campos, Brunno M., Martinez, Alberto R.M., Castellano, Gabriela, França Junior, Marcondes C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411904/
https://www.ncbi.nlm.nih.gov/pubmed/30584013
http://dx.doi.org/10.1016/j.nicl.2018.101633
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author Casseb, Raphael F.
de Campos, Brunno M.
Martinez, Alberto R.M.
Castellano, Gabriela
França Junior, Marcondes C.
author_facet Casseb, Raphael F.
de Campos, Brunno M.
Martinez, Alberto R.M.
Castellano, Gabriela
França Junior, Marcondes C.
author_sort Casseb, Raphael F.
collection PubMed
description Sensory-motor integration models have been proposed aiming to explain how the brain uses sensory information to guide and check the planning and execution of movements. Sensory neuronopathy (SN) is a peculiar disease characterized by exclusive, severe and widespread sensory loss. It is a valuable condition to investigate how sensory deafferentation impacts brain organization. We thus recruited patients with clinical and electrophysiological criteria for SN to perform structural and functional MRI analyses. We investigated volumetric changes in gray matter (GM) using anatomical images; the microstructure of WM within segmented regions of interest (ROI), via diffusion images; and brain activation related to a finger tapping task. All significant results were related to the long disease duration subgroup of patients. Structural analysis showed hypertrophy of the caudate nucleus, whereas the diffusion study identified reduction of fractional anisotropy values in ROIs located around the thalamus and the striatum. We also found differences regarding finger-tapping activation in the posterior parietal regions and in the medial areas of the cerebellum. Our results stress the role of the caudate nucleus over the other basal ganglia in the sensory-motor integration models, and suggest an inhibitory function of a recently discovered tract between the thalamus and the striatum. Overall, our findings confirm plasticity in the adult brain and open new avenues to design neurorehabilitation strategies.
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spelling pubmed-64119042019-03-22 Selective sensory deafferentation induces structural and functional brain plasticity Casseb, Raphael F. de Campos, Brunno M. Martinez, Alberto R.M. Castellano, Gabriela França Junior, Marcondes C. Neuroimage Clin Article Sensory-motor integration models have been proposed aiming to explain how the brain uses sensory information to guide and check the planning and execution of movements. Sensory neuronopathy (SN) is a peculiar disease characterized by exclusive, severe and widespread sensory loss. It is a valuable condition to investigate how sensory deafferentation impacts brain organization. We thus recruited patients with clinical and electrophysiological criteria for SN to perform structural and functional MRI analyses. We investigated volumetric changes in gray matter (GM) using anatomical images; the microstructure of WM within segmented regions of interest (ROI), via diffusion images; and brain activation related to a finger tapping task. All significant results were related to the long disease duration subgroup of patients. Structural analysis showed hypertrophy of the caudate nucleus, whereas the diffusion study identified reduction of fractional anisotropy values in ROIs located around the thalamus and the striatum. We also found differences regarding finger-tapping activation in the posterior parietal regions and in the medial areas of the cerebellum. Our results stress the role of the caudate nucleus over the other basal ganglia in the sensory-motor integration models, and suggest an inhibitory function of a recently discovered tract between the thalamus and the striatum. Overall, our findings confirm plasticity in the adult brain and open new avenues to design neurorehabilitation strategies. Elsevier 2018-12-11 /pmc/articles/PMC6411904/ /pubmed/30584013 http://dx.doi.org/10.1016/j.nicl.2018.101633 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Casseb, Raphael F.
de Campos, Brunno M.
Martinez, Alberto R.M.
Castellano, Gabriela
França Junior, Marcondes C.
Selective sensory deafferentation induces structural and functional brain plasticity
title Selective sensory deafferentation induces structural and functional brain plasticity
title_full Selective sensory deafferentation induces structural and functional brain plasticity
title_fullStr Selective sensory deafferentation induces structural and functional brain plasticity
title_full_unstemmed Selective sensory deafferentation induces structural and functional brain plasticity
title_short Selective sensory deafferentation induces structural and functional brain plasticity
title_sort selective sensory deafferentation induces structural and functional brain plasticity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411904/
https://www.ncbi.nlm.nih.gov/pubmed/30584013
http://dx.doi.org/10.1016/j.nicl.2018.101633
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