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Gene gun DNA immunization of cattle induces humoral and CD4 T-cell-mediated immune responses against the Theileria parva polymorphic immunodominant molecule

Theileria parva kills over one million cattle annually in sub-Saharan Africa. Parasite genetic complexity, cellular response immunodominance, and bovine MHC diversity have precluded traditional vaccine development. One potential solution is gene gun (GG) immunization, which enables simultaneous admi...

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Detalles Bibliográficos
Autores principales:	Fry, Lindsay M., Bastos, Reginaldo G., Stone, Brad C., Williams, Laura B., Knowles, Donald P., Murphy, Sean C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411927/ https://www.ncbi.nlm.nih.gov/pubmed/30782490 http://dx.doi.org/10.1016/j.vaccine.2019.02.009

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