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Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome

OBJECTIVE: To investigate, based on a putative abnormal neural processing of disgusting signals in Prader Willi syndrome (PWS) patients, the brain response to visual representations of disgusting food in PWS using functional MRI (fMRI). METHODS: Twenty-one genetically-confirmed PWS patients, 30 age-...

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Autores principales: Blanco-Hinojo, Laura, Pujol, Jesus, Esteba-Castillo, Susanna, Martínez-Vilavella, Gerard, Giménez-Palop, Olga, Gabau, Elisabeth, Casamitjana, Laia, Deus, Joan, Novell, Ramón, Caixàs, Assumpta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412080/
https://www.ncbi.nlm.nih.gov/pubmed/30639180
http://dx.doi.org/10.1016/j.nicl.2019.101662
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author Blanco-Hinojo, Laura
Pujol, Jesus
Esteba-Castillo, Susanna
Martínez-Vilavella, Gerard
Giménez-Palop, Olga
Gabau, Elisabeth
Casamitjana, Laia
Deus, Joan
Novell, Ramón
Caixàs, Assumpta
author_facet Blanco-Hinojo, Laura
Pujol, Jesus
Esteba-Castillo, Susanna
Martínez-Vilavella, Gerard
Giménez-Palop, Olga
Gabau, Elisabeth
Casamitjana, Laia
Deus, Joan
Novell, Ramón
Caixàs, Assumpta
author_sort Blanco-Hinojo, Laura
collection PubMed
description OBJECTIVE: To investigate, based on a putative abnormal neural processing of disgusting signals in Prader Willi syndrome (PWS) patients, the brain response to visual representations of disgusting food in PWS using functional MRI (fMRI). METHODS: Twenty-one genetically-confirmed PWS patients, 30 age- and sex-matched and 28 BMI-matched control subjects viewed a movie depicting disgusting food-related scenes interspersed with scenes of appetizing food while fMRI was acquired. Brain activation maps were compared between groups and correlated with disgust and hunger ratings. RESULTS: At the cortical level, the response to disgusting food representations in PWS patients was qualitatively similar to that of control subjects, albeit less extensive, and engaged brain regions typically related to visually-evoked disgust, such as the anterior insula/frontal operculum, the lateral frontal cortex and visual areas. By contrast, activation was almost absent in limbic structures directly concerned with the regulation of instinctive behavior robustly activated in control subjects, such as the hypothalamus, amygdala/hippocampus and periaqueductal gray. CONCLUSIONS: Our study provides novel insights into the neural substrates of appetite control in a genetically-mediated cause of obesity. The presence of significant cortical changes further indicates that PWS patients consciously process disgusting stimuli, but the virtual absence of response in deep, limbic structures suggests that disgusting signals do not adequately reach the primary brain system for the appetite control.
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spelling pubmed-64120802019-03-21 Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome Blanco-Hinojo, Laura Pujol, Jesus Esteba-Castillo, Susanna Martínez-Vilavella, Gerard Giménez-Palop, Olga Gabau, Elisabeth Casamitjana, Laia Deus, Joan Novell, Ramón Caixàs, Assumpta Neuroimage Clin Article OBJECTIVE: To investigate, based on a putative abnormal neural processing of disgusting signals in Prader Willi syndrome (PWS) patients, the brain response to visual representations of disgusting food in PWS using functional MRI (fMRI). METHODS: Twenty-one genetically-confirmed PWS patients, 30 age- and sex-matched and 28 BMI-matched control subjects viewed a movie depicting disgusting food-related scenes interspersed with scenes of appetizing food while fMRI was acquired. Brain activation maps were compared between groups and correlated with disgust and hunger ratings. RESULTS: At the cortical level, the response to disgusting food representations in PWS patients was qualitatively similar to that of control subjects, albeit less extensive, and engaged brain regions typically related to visually-evoked disgust, such as the anterior insula/frontal operculum, the lateral frontal cortex and visual areas. By contrast, activation was almost absent in limbic structures directly concerned with the regulation of instinctive behavior robustly activated in control subjects, such as the hypothalamus, amygdala/hippocampus and periaqueductal gray. CONCLUSIONS: Our study provides novel insights into the neural substrates of appetite control in a genetically-mediated cause of obesity. The presence of significant cortical changes further indicates that PWS patients consciously process disgusting stimuli, but the virtual absence of response in deep, limbic structures suggests that disgusting signals do not adequately reach the primary brain system for the appetite control. Elsevier 2019-01-04 /pmc/articles/PMC6412080/ /pubmed/30639180 http://dx.doi.org/10.1016/j.nicl.2019.101662 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Blanco-Hinojo, Laura
Pujol, Jesus
Esteba-Castillo, Susanna
Martínez-Vilavella, Gerard
Giménez-Palop, Olga
Gabau, Elisabeth
Casamitjana, Laia
Deus, Joan
Novell, Ramón
Caixàs, Assumpta
Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome
title Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome
title_full Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome
title_fullStr Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome
title_full_unstemmed Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome
title_short Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome
title_sort lack of response to disgusting food in the hypothalamus and related structures in prader willi syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412080/
https://www.ncbi.nlm.nih.gov/pubmed/30639180
http://dx.doi.org/10.1016/j.nicl.2019.101662
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